Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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| Original language | English |
|---|---|
| Article number | 650 |
| Journal / Publication | Communications Biology |
| Volume | 4 |
| Online published | 1 Jun 2021 |
| Publication status | Published - 2021 |
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| DOI | DOI |
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| Attachment(s) | Documents
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| Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85107456029&origin=recordpage |
| Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(18ad664f-3ad8-4a66-a733-70aa5611bb68).html |
Abstract
Carbapenem-resistant and hypervirulent K. pneumoniae (CR-HvKP) strains that have emerged recently have caused infections of extremely high mortality in various countries. In this study, we discovered a conjugative plasmid that encodes carbapenem resistance and hypervirulence in a clinical ST86 K2 CR-HvKP, namely 17ZR-91. The conjugative plasmid (p17ZR-91-Vir-KPC) was formed by fusion of a non-conjugative pLVPK-like plasmid and a conjugative blaKPC-2- bearing plasmid and is present dynamically with two other non-fusion plasmids. Conjugation of p17ZR-91-Vir-KPC to other K. pneumoniae enabled them to rapidly express the carbapenem resistance and hypervirulence phenotypes. More importantly, genome analysis provided direct evidence that p17ZR-91-Vir-KPC could be directly transmitted from K2 CR-HvKP strain, 17ZR-91, to ST11 clinical K. pneumoniae strains to convert them into ST11 CR-HvKP strains, which explains the evolutionary mechanisms of recently emerged ST11 CR-HvKP strains.
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Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae. / Xie, Miaomiao; Yang, Xuemei; Xu, Qi et al.
In: Communications Biology, Vol. 4, 650, 2021.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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