Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

4 Scopus Citations
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Author(s)

  • Yingying Lu
  • Feng Liu
  • Gangling Tong
  • Feng Qiu
  • Pinhong Song
  • And 7 others
  • Xiaolin Wang
  • Xiafei Zou
  • Deyun Wan
  • Miao Cui
  • Yunsheng Xu
  • Zhihua Zheng
  • Peng Hong

Detail(s)

Original languageEnglish
Article number107
Journal / PublicationSignal Transduction and Targeted Therapy
Volume6
Online published3 Mar 2021
Publication statusPublished - 2021

Link(s)

Abstract

Synthetic glucocorticoid dexamethasone is the first trial-proven drug that reduces COVID-19 mortality by suppressing immune system. In contrast, interferons are a crucial component of host antiviral immunity and can be directly suppressed by glucocorticoids. To investigate whether therapeutic interferons can compensate glucocorticoids-induced loss of antiviral immunity, we retrospectively analyzed a cohort of 387 PCR-confirmed COVID-19 patients with quasi-random exposure to interferons and conditional exposure to glucocorticoids. Among patients receiving glucocorticoids, early interferon therapy was associated with earlier hospital discharge (adjusted HR 1.68, 95% CI 1.19–2.37) and symptom relief (adjusted HR 1.48, 95% CI 1.06–2.08), while these associations were insignificant among glucocorticoids nonusers. Early interferon therapy was also associated with lower prevalence of prolonged viral shedding (adjusted OR 0.24, 95% CI 0.10–0.57) only among glucocorticoids users. Additionally, these associations were glucocorticoid cumulative dose- and timing-dependent. These findings reveal potential therapeutic synergy between interferons and glucocorticoids in COVID-19 that warrants further investigation.

Research Area(s)

Citation Format(s)

Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19. / Lu, Yingying; Liu, Feng; Tong, Gangling; Qiu, Feng; Song, Pinhong; Wang, Xiaolin; Zou, Xiafei; Wan, Deyun; Cui, Miao; Xu, Yunsheng; Zheng, Zhihua; Hong, Peng.

In: Signal Transduction and Targeted Therapy, Vol. 6, 107, 2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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