Chromosome-Level Haplotype Assembly for Equus asinu

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Yonghan Yu
  • Zicheng Zhao
  • Yinan Wang
  • Xiaobo Qian
  • Yonghui Wang
  • Shengbin Li
  • Changfa Wang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number738105
Journal / PublicationFrontiers in Genetics
Volume13
Online published27 May 2022
Publication statusPublished - May 2022

Link(s)

Abstract

Background: Haplotype provides significant insights into understanding genomes at both individual and population levels. However, research on many non-model organisms is still based on independent genetic variations due to the lack of haplotype. Results: We conducted haplotype assembling for Equus asinu, a non-model organism that plays a vital role in human civilization. We described the hybrid single individual assembled haplotype of the Dezhou donkey based on the high-depth sequencing data from single-molecule real-time sequencing (x30), Illumina short-read sequencing (x211), and high-throughput chromosome conformation capture (x56). We assembled a near-complete haplotype for the high-depth sequenced Dezhou donkey individual and a phased cohort for the resequencing data of the donkey population. Conclusion: Here, we described the complete chromosome-scale haplotype of the Dezhou donkey with more than a 99.7% phase rate. We further phased a cohort of 156 donkeys to form a donkey haplotype dataset with more than 39 million genetic variations.

Research Area(s)

  • donkey, Equus, haplotype, population analysis, phase, DRAFT POWER RESOURCE, GENETIC DIVERSITY, GENOME VARIATION, DONKEY MILK, MAP, REVEALS, HISTORY, RICE

Citation Format(s)

Chromosome-Level Haplotype Assembly for Equus asinu. / Miao, Xinyao; Yu, Yonghan; Zhao, Zicheng; Wang, Yinan; Qian, Xiaobo; Wang, Yonghui; Li, Shengbin; Wang, Changfa.

In: Frontiers in Genetics, Vol. 13, 738105, 05.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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