Chromosomal and plasmid-borne tigecycline resistance genes tet(X3) and tet(X4) in dairy cows in a Chinese farm

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Rong Zhang
  • Ning Dong
  • Yu Zeng
  • Zhangqi Shen
  • Jiauyue Lu
  • Congcong Liu
  • Zhuo-an Huang
  • Qiaoling Sun
  • Qipeng Cheng
  • Lingbing Shu
  • Jiachang Cai
  • Edward Waichi Chan
  • Dejun Liu
  • Gongxiang Chen
  • Yang Wang

Detail(s)

Original languageEnglish
Journal / PublicationAntimicrobial Agents and Chemotherapy
Volume64
Issue number11
Online published17 Aug 2020
Publication statusPublished - 20 Oct 2020

Abstract

We isolated 47 Acinetobacter spp. carrying tet(X3) and 4 ST767 E. coli strains carrying tet(X4) from 296 rectal swab samples from dairy cows in a Chinese farm. tet(X3) was located on chromosomes or diverse plasmids, and tet(X4) was located on IncFIBκ/FIA(HI1)/X1 non-transferable plasmid. Co-existence of tet(X3) and carbapenemase genes including blaOXA-58 and blaNDM-1 were detected in 9 Acinetobacter spp. These findings suggested the use of tetracycline and other antibiotics in food production warrants urgent attention.

Research Area(s)

  • Acinetobacter spp., dairy cow, E. coli, epidemiology, GI tract, tet(X3), tet(X4), tigecycline, WGS

Citation Format(s)

Chromosomal and plasmid-borne tigecycline resistance genes tet(X3) and tet(X4) in dairy cows in a Chinese farm. / Zhang, Rong; Dong, Ning; Zeng, Yu; Shen, Zhangqi; Lu, Jiauyue; Liu, Congcong; Huang, Zhuo-an; Sun, Qiaoling; Cheng, Qipeng; Shu, Lingbing; Cai, Jiachang; Waichi Chan, Edward; Liu, Dejun; Chen, Gongxiang; Wang, Yang; Chen, Sheng.

In: Antimicrobial Agents and Chemotherapy, Vol. 64, No. 11, 20.10.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review