Chromosomal and plasmid-borne tigecycline resistance genes tet(X3) and tet(X4) in dairy cows in a Chinese farm

Rong Zhang; Ning Dong; Yu Zeng; Zhangqi Shen; Jiauyue Lu; Congcong Liu; Zhuo-an Huang; Qiaoling Sun; Qipeng Cheng; Lingbing Shu; Jiachang Cai; Edward Waichi Chan; Dejun Liu; Gongxiang Chen; Yang Wang; Sheng Chen

doi:10.1128/AAC.00674-20

Chromosomal and plasmid-borne tigecycline resistance genes tet(X3) and tet(X4) in dairy cows in a Chinese farm

Rong Zhang, Ning Dong, Yu Zeng, Zhangqi Shen, Jiauyue Lu, Congcong Liu, Zhuo-an Huang, Qiaoling Sun, Qipeng Cheng, Lingbing Shu, Jiachang Cai, Edward Waichi Chan, Dejun Liu, Gongxiang Chen, Yang Wang^*, Sheng Chen^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

23 Citations (Scopus)

Abstract

We isolated 47 Acinetobacter spp. carrying tet(X3) and 4 ST767 E. coli strains carrying tet(X4) from 296 rectal swab samples from dairy cows in a Chinese farm. tet(X3) was located on chromosomes or diverse plasmids, and tet(X4) was located on IncFIBκ/FIA(HI1)/X1 non-transferable plasmid. Co-existence of tet(X3) and carbapenemase genes including bla_OXA-58 and blaN_DM-1 were detected in 9 Acinetobacter spp. These findings suggested the use of tetracycline and other antibiotics in food production warrants urgent attention.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	64
Issue number	11
Online published	17 Aug 2020
DOIs	https://doi.org/10.1128/AAC.00674-20
Publication status	Published - 20 Oct 2020

Research Keywords

Acinetobacter spp.
dairy cow
E. coli
epidemiology
GI tract
tet(X3)
tet(X4)
tigecycline
WGS

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title = "Chromosomal and plasmid-borne tigecycline resistance genes tet(X3) and tet(X4) in dairy cows in a Chinese farm",

abstract = "We isolated 47 Acinetobacter spp. carrying tet(X3) and 4 ST767 E. coli strains carrying tet(X4) from 296 rectal swab samples from dairy cows in a Chinese farm. tet(X3) was located on chromosomes or diverse plasmids, and tet(X4) was located on IncFIBκ/FIA(HI1)/X1 non-transferable plasmid. Co-existence of tet(X3) and carbapenemase genes including blaOXA-58 and blaNDM-1 were detected in 9 Acinetobacter spp. These findings suggested the use of tetracycline and other antibiotics in food production warrants urgent attention.",

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author = "Rong Zhang and Ning Dong and Yu Zeng and Zhangqi Shen and Jiauyue Lu and Congcong Liu and Zhuo-an Huang and Qiaoling Sun and Qipeng Cheng and Lingbing Shu and Jiachang Cai and Chan, {Edward Waichi} and Dejun Liu and Gongxiang Chen and Yang Wang and Sheng Chen",

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doi = "10.1128/AAC.00674-20",

language = "English",

volume = "64",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Chromosomal and plasmid-borne tigecycline resistance genes tet(X3) and tet(X4) in dairy cows in a Chinese farm

AU - Zhang, Rong

AU - Dong, Ning

AU - Zeng, Yu

AU - Shen, Zhangqi

AU - Lu, Jiauyue

AU - Liu, Congcong

AU - Huang, Zhuo-an

AU - Sun, Qiaoling

AU - Cheng, Qipeng

AU - Shu, Lingbing

AU - Cai, Jiachang

AU - Chan, Edward Waichi

AU - Liu, Dejun

AU - Chen, Gongxiang

AU - Wang, Yang

AU - Chen, Sheng

PY - 2020/10/20

Y1 - 2020/10/20

N2 - We isolated 47 Acinetobacter spp. carrying tet(X3) and 4 ST767 E. coli strains carrying tet(X4) from 296 rectal swab samples from dairy cows in a Chinese farm. tet(X3) was located on chromosomes or diverse plasmids, and tet(X4) was located on IncFIBκ/FIA(HI1)/X1 non-transferable plasmid. Co-existence of tet(X3) and carbapenemase genes including blaOXA-58 and blaNDM-1 were detected in 9 Acinetobacter spp. These findings suggested the use of tetracycline and other antibiotics in food production warrants urgent attention.

AB - We isolated 47 Acinetobacter spp. carrying tet(X3) and 4 ST767 E. coli strains carrying tet(X4) from 296 rectal swab samples from dairy cows in a Chinese farm. tet(X3) was located on chromosomes or diverse plasmids, and tet(X4) was located on IncFIBκ/FIA(HI1)/X1 non-transferable plasmid. Co-existence of tet(X3) and carbapenemase genes including blaOXA-58 and blaNDM-1 were detected in 9 Acinetobacter spp. These findings suggested the use of tetracycline and other antibiotics in food production warrants urgent attention.

KW - Acinetobacter spp.

KW - dairy cow

KW - E. coli

KW - epidemiology

KW - GI tract

KW - tet(X3)

KW - tet(X4)

KW - tigecycline

KW - WGS

KW - Acinetobacter spp.

KW - dairy cow

KW - E. coli

KW - epidemiology

KW - GI tract

KW - tet(X3)

KW - tet(X4)

KW - tigecycline

KW - WGS

KW - Acinetobacter spp.

KW - dairy cow

KW - E. coli

KW - epidemiology

KW - GI tract

KW - tet(X3)

KW - tet(X4)

KW - tigecycline

KW - WGS

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U2 - 10.1128/AAC.00674-20

DO - 10.1128/AAC.00674-20

M3 - RGC 21 - Publication in refereed journal

C2 - 32816739

SN - 0066-4804

VL - 64

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Chromosomal and plasmid-borne tigecycline resistance genes tet(X3) and tet(X4) in dairy cows in a Chinese farm

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