Cholecystokinin release triggered by NMDA receptors produces LTP and sound–sound associative memory

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)6397-6406
Journal / PublicationProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number13
Online published8 Mar 2019
Publication statusPublished - 26 Mar 2019

Abstract

Memory is stored in neural networks via changes in synaptic strength mediated in part by NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B receptor (CCKBR) antagonist blocks high-frequency stimulation-induced neocortical LTP, whereas local infusion of CCK induces LTP. CCK−/− mice lacked neocortical LTP and showed deficits in a cue–cue associative learning paradigm; and administration of CCK rescued associative learning deficits. High-frequency stimulation-induced neocortical LTP was completely blocked by either the NMDAR antagonist or the CCKBR antagonist, while application of either NMDA or CCK induced LTP after low-frequency stimulation. In the presence of CCK, LTP was still induced even after blockade of NMDARs. Local application of NMDA induced the release of CCK in the neocortex. These findings suggest that NMDARs control the release of CCK, which enables neocortical LTP and the formation of cue–cue associative memory.

Research Area(s)

  • cholecystokinin, NMDA receptor, long-term potentiation, memory, entorhinal cortex

Citation Format(s)

Cholecystokinin release triggered by NMDA receptors produces LTP and sound–sound associative memory. / Chen, Xi; Li, Xiao; Wong, Yin Ting et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 13, 26.03.2019, p. 6397-6406.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review