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ChitoSilkBioPatch: A bio-inspired wound dressing scaffold for antibiotic-free diabetic wound management

  • Dorsa Dehghan-Baniani (Co-first Author)
  • , Babak Mehrjou (Co-first Author)
  • , Yucong Li (Co-first Author)
  • , Zhaowei Jiang
  • , Xiaomin Lu
  • , Yin Xiao
  • , Huanxiong Chen
  • , Tsz Lam Yiu
  • , Chi Chiu Wang
  • , Hongkai Wu
  • , Gang Li*
  • , Paul K. Chu*
  • , Wayne Yuk Wai Lee*
    • *Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Abstract

Delayed wound healing in diabetic patients poses significant clinical challenges, increasing risks of severe foot infections and potential limb amputation. To address infection risks and antibiotic resistance, we developed an antibiotic-free composite, “ChitoSilkBioPatch,” integrating maleimide-releasing chitosan hydrogels with decellularized fetal membrane (dACM) and a biomimetic stretchable silk mesh. This innovative scaffold combines potent antibacterial activity against Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria through nanotopographical cues, dACM, oligochitosan, and conjugated maleimides, alongside robust regenerative properties. The silk mesh mimics skin's tensile strength and stretchability, while the hydrogel provides viscoelasticity akin to skin. In vivo, ChitoSilkBioPatch demonstrates strong anti-inflammatory effects, accelerates epidermal and dermal regeneration, and enhances angiogenesis and immunomodulation, offering a promising solution for chronic diabetic wound healing.

© 2026 The Author(s). VIEW published by Shanghai Fuji Technology Consulting Co., Ltd, authorized by China Professional Community of Experimental Medicine, National Association Health Industry Enterprise Management (CPCEM) and John Wiley & Sons Australia, Ltd.
Original languageEnglish
Article number20250140
Number of pages25
JournalVIEW
Online published4 Feb 2026
DOIs
Publication statusOnline published - 4 Feb 2026

Funding

This research was financially supported by Theme Base Scheme (TRS T13-602/21-N), Hong Kong RGC (#16309920, #16300622, #16309421, and #16300323), Hong Kong ITC (grant ITC-CNERC14SC01), Guangdong Basic and Applied Basic Research Foundation (2022B1515130010), Guangdong Natural Science Foundation (GDST23SC01), Hong Kong PDFS-RGC Postdoctoral Fellowship Scheme (PDFS2122-1S08 and CityU 9061014), Hong Kong HMRF (Health and Medical Research Fund) (2120972 and CityU 9211320), start-up grant from The Chinese University of Hong Kong (Ref. nos. 4930991 and 4930992), National Natural Science Foundation of China (82160435 and 81902270), Area of Excellence (Ref. no. AoE/M-402/20), University Grants Committee, Research Matching Grant Scheme, and 2020 Rising Star Award from American Society for Bone and Mineral Research. These funding bodies played no role in the design of the study and collection, analysis, and interpretation of data, and in writing the manuscript.

Research Keywords

  • antibacterial wound dressing scaffold
  • decellularized amniotic-chorionic membrane extracellular matrix
  • diabetic wound healing
  • maleimide-grafted chitosan hydrogel
  • stretchable silk

RGC Funding Information

  • RGC-funded

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