Chiral Restructuring of Peptide Enantiomers on Gold Nanomaterials

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

11 Scopus Citations
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Author(s)

  • Joseph M. Slocik
  • Patrick B. Dennis
  • Alexander O. Govorov
  • Nicholas M. Bedford
  • Rajesh R. Naik

Detail(s)

Original languageEnglish
Pages (from-to)2612-2620
Journal / PublicationACS Biomaterials Science and Engineering
Volume6
Issue number5
Online published28 Oct 2019
Publication statusPublished - 11 May 2020
Externally publishedYes

Abstract

The use of biomolecules has been invaluable at generating and controlling optical chirality in nanomaterials; however, the structure and properties of the chiral biotemplate are not well understood due to the complexity of peptide-nanoparticle interactions. In this study, we show that the complex interactions between d-peptides and gold nanomaterials led to a chiral restructuring of peptides as demonstrated by circular dichroism and proteolytic cleavage of d-peptides via gold-mediated inversion of peptide chirality. The gold nanoparticles synthesized using d-peptide produce a highly ordered atomic surface and restructured peptide bonds for enzyme cleavage. Differences in gold nanoparticle catalyzed reduction of 4-nitrophenol were observed on the basis of the chiral peptide used in nanoparticle synthesis. Notably, the proteolytic cleavage of d-peptides on gold provides an opportunity for designing nanoparticle based therapeutics to treat peptide venoms, access new chemistries, or modulate the catalytic activity of nanomaterials.

Research Area(s)

  • chiral inversion, circular dichroism, d-peptide cleavage, nanoparticle, peptide

Citation Format(s)

Chiral Restructuring of Peptide Enantiomers on Gold Nanomaterials. / Slocik, Joseph M.; Dennis, Patrick B.; Govorov, Alexander O. et al.

In: ACS Biomaterials Science and Engineering, Vol. 6, No. 5, 11.05.2020, p. 2612-2620.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review