Chemodivergent synthesis of N-(pyridin-2-yl)amides and 3-bromoimidazo[1,2-a]pyridines from α-bromoketones and 2-aminopyridines

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

8 Scopus Citations
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Author(s)

  • Lixue Lu
  • Haipin Zhou
  • Feijie Xu
  • Cong Ma
  • Zhangjian Huang
  • Jinyi Xu
  • Shengtao Xu

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)34671-34676
Journal / PublicationRSC Advances
Volume9
Issue number59
Online published28 Oct 2019
Publication statusPublished - 2019

Link(s)

Abstract

N-(Pyridin-2-yl)amides and 3-bromoimidazo[1,2-a]pyridines were synthesized respectively from alpha-bromoketones and 2-aminopyridine under different reaction conditions. N-(Pyridin-2-yl)amides were formed in toluene via C-C bond cleavage promoted by I-2 and TBHP and the reaction conditions were mild and metal-free. Whereas 3-bromoimidazopyridines were obtained in ethyl acetate via one-pot tandem cyclization/bromination when only TBHP was added, the cyclization to form imidazopyridines was promoted by the further bromination, no base was needed, and the versatile 3-bromoimidazopyridines could be further transferred to other skeletons.

Research Area(s)

  • AEROBIC OXIDATIVE SYNTHESIS, AMIDE BOND FORMATION, CARBOXYLIC-ACIDS, COPPER, INHIBITORS, CLEAVAGE, KETONES, DESIGN, ESTERS, AMIDATION

Citation Format(s)

Chemodivergent synthesis of N-(pyridin-2-yl)amides and 3-bromoimidazo[1,2-a]pyridines from α-bromoketones and 2-aminopyridines. / Liu, Yanpeng; Lu, Lixue; Zhou, Haipin; Xu, Feijie; Ma, Cong; Huang, Zhangjian; Xu, Jinyi; Xu, Shengtao.

In: RSC Advances, Vol. 9, No. 59, 2019, p. 34671-34676.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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