Chemical Biology Tools for Protein Lysine Acylation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

View graph of relations

Author(s)

  • Yusheng Xie
  • Shubo Du
  • Min Liu
  • Zhiqiang Xu
  • Xiaojie Wang
  • Jia Xuan Kee
  • Fan Yi
  • Shao Q. Yao

Detail(s)

Original languageEnglish
Journal / PublicationAngewandte Chemie - International Edition
Volume61
Issue number21
Online published18 Mar 2022
Publication statusPublished - 16 May 2022

Abstract

Lysine acylation plays pivotal roles in cell physiology, including DNA transcription and repair, signal transduction, immune defense, metabolism, and many other key cellular processes. Molecular mechanisms of dysregulated lysine acylation are closely involved in the pathophysiological progress of many human diseases, most notably cancers. In recent years, chemical biology tools have become instrumental in studying the function of post-translational modifications (PTMs), identifying new “writers”, “erasers” and “readers”, and in targeted therapies. Here, we describe key developments in chemical biology approaches that have advanced the study of lysine acylation and its regulatory proteins (2016–2021). We further discuss the discovery of ligands (inhibitors and PROTACs) that are capable of targeting regulators of lysine acylation. Next, we discuss some current challenges of these chemical biology probes and suggest how chemists and biologists can utilize chemical probes with more discriminating capacity. Finally, we suggest some critical considerations in future studies of PTMs from our perspective.

Research Area(s)

  • Chemical Probes, Epigenetics, Lysine Acylation, PROTAC, Protein Machinery

Citation Format(s)

Chemical Biology Tools for Protein Lysine Acylation. / Xie, Yusheng; Du, Shubo; Liu, Zhiyang; Liu, Min; Xu, Zhiqiang; Wang, Xiaojie; Kee, Jia Xuan; Yi, Fan; Sun, Hongyan; Yao, Shao Q.

In: Angewandte Chemie - International Edition, Vol. 61, No. 21, 16.05.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review