Characterization of New Gambierones Produced by Gambierdiscus balechii 1123M1M10

Xiaowan Liu; Yihan Ma; Jiajun Wu; Qizhao Yin; Pengbin Wang; Jingyi Zhu; Leo Lai Chan; Bin Wu

doi:10.3390/md21010003

Characterization of New Gambierones Produced by Gambierdiscus balechii 1123M1M10

Xiaowan Liu, Yihan Ma, Jiajun Wu, Qizhao Yin, Pengbin Wang, Jingyi Zhu, Leo Lai Chan^*, Bin Wu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Abstract

The benthic dinoflagellate genus Gambierdiscus is the primary producer of toxins responsible for ciguatera poisoning (CP), a food intoxication endemic in tropical and subtropical areas of the world. We used high-performance liquid chromatography tandem high-resolution mass spectrometry (HPLC-HRMS) to investigate the toxin profile of Gambierdiscus balechii 1123M1M10, which was obtained from Marakei Island (2°01 ' N, 173°15 ' E), Republic of Kiribati, located in the central Pacific Ocean. Four new gambierone analogues including 12,13-dihydro-44-methylgambierone, 38-dehydroxy-12,13-dihydro-44-methylgambierone, 38-dehydroxy-44-methylgambierone, and desulfo-hydroxyl gambierone, and two known compounds, gambierone and 44-methylgambierone, were proposed by analyzing their fragmentation behaviors and pathways. Our findings provide new insights into the toxin profile of Gambierdiscus balechii 1123M1M10, which can be used as a biomarker for species identification, and lay the foundation for further toxin isolation and bioactivity studies of gambierones. © 2022 by the authors.

Original language	English
Article number	3
Journal	Marine Drugs
Volume	21
Issue number	1
Online published	21 Dec 2022
DOIs	https://doi.org/10.3390/md21010003
Publication status	Published - Jan 2023

Funding

This research was funded by the General Research Fund of the Hong Kong Research Grants Council (No. 11104821), the National Natural Science Foundation of China (No. 42176098), and the Collaborative Research Fund of the Hong Kong Research Grants Council (No. C7013-19GF).

Research Keywords

Gambierdiscus balechii
gambierone
dihydro-44-methylgambierone
dehydroxy-44-methylgambierone
desulfo-hydroxyl gambierone
POLYETHER COMPOUND
DINOFLAGELLATE
DINOPHYCEAE
CIGUATOXIN
TOXICUS
MAITOTOXIN
CIGUATERA
STRAINS
FISH

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

RGC Funding Information

RGC-funded

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md21010003

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title = "Characterization of New Gambierones Produced by Gambierdiscus balechii 1123M1M10",

abstract = "The benthic dinoflagellate genus Gambierdiscus is the primary producer of toxins responsible for ciguatera poisoning (CP), a food intoxication endemic in tropical and subtropical areas of the world. We used high-performance liquid chromatography tandem high-resolution mass spectrometry (HPLC-HRMS) to investigate the toxin profile of Gambierdiscus balechii 1123M1M10, which was obtained from Marakei Island (2°01 ' N, 173°15 ' E), Republic of Kiribati, located in the central Pacific Ocean. Four new gambierone analogues including 12,13-dihydro-44-methylgambierone, 38-dehydroxy-12,13-dihydro-44-methylgambierone, 38-dehydroxy-44-methylgambierone, and desulfo-hydroxyl gambierone, and two known compounds, gambierone and 44-methylgambierone, were proposed by analyzing their fragmentation behaviors and pathways. Our findings provide new insights into the toxin profile of Gambierdiscus balechii 1123M1M10, which can be used as a biomarker for species identification, and lay the foundation for further toxin isolation and bioactivity studies of gambierones. {\textcopyright} 2022 by the authors.",

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author = "Xiaowan Liu and Yihan Ma and Jiajun Wu and Qizhao Yin and Pengbin Wang and Jingyi Zhu and Chan, {Leo Lai} and Bin Wu",

year = "2023",

month = jan,

doi = "10.3390/md21010003",

language = "English",

volume = "21",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "1",

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T1 - Characterization of New Gambierones Produced by Gambierdiscus balechii 1123M1M10

AU - Liu, Xiaowan

AU - Ma, Yihan

AU - Wu, Jiajun

AU - Yin, Qizhao

AU - Wang, Pengbin

AU - Zhu, Jingyi

AU - Chan, Leo Lai

AU - Wu, Bin

PY - 2023/1

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N2 - The benthic dinoflagellate genus Gambierdiscus is the primary producer of toxins responsible for ciguatera poisoning (CP), a food intoxication endemic in tropical and subtropical areas of the world. We used high-performance liquid chromatography tandem high-resolution mass spectrometry (HPLC-HRMS) to investigate the toxin profile of Gambierdiscus balechii 1123M1M10, which was obtained from Marakei Island (2°01 ' N, 173°15 ' E), Republic of Kiribati, located in the central Pacific Ocean. Four new gambierone analogues including 12,13-dihydro-44-methylgambierone, 38-dehydroxy-12,13-dihydro-44-methylgambierone, 38-dehydroxy-44-methylgambierone, and desulfo-hydroxyl gambierone, and two known compounds, gambierone and 44-methylgambierone, were proposed by analyzing their fragmentation behaviors and pathways. Our findings provide new insights into the toxin profile of Gambierdiscus balechii 1123M1M10, which can be used as a biomarker for species identification, and lay the foundation for further toxin isolation and bioactivity studies of gambierones. © 2022 by the authors.

AB - The benthic dinoflagellate genus Gambierdiscus is the primary producer of toxins responsible for ciguatera poisoning (CP), a food intoxication endemic in tropical and subtropical areas of the world. We used high-performance liquid chromatography tandem high-resolution mass spectrometry (HPLC-HRMS) to investigate the toxin profile of Gambierdiscus balechii 1123M1M10, which was obtained from Marakei Island (2°01 ' N, 173°15 ' E), Republic of Kiribati, located in the central Pacific Ocean. Four new gambierone analogues including 12,13-dihydro-44-methylgambierone, 38-dehydroxy-12,13-dihydro-44-methylgambierone, 38-dehydroxy-44-methylgambierone, and desulfo-hydroxyl gambierone, and two known compounds, gambierone and 44-methylgambierone, were proposed by analyzing their fragmentation behaviors and pathways. Our findings provide new insights into the toxin profile of Gambierdiscus balechii 1123M1M10, which can be used as a biomarker for species identification, and lay the foundation for further toxin isolation and bioactivity studies of gambierones. © 2022 by the authors.

KW - Gambierdiscus balechii

KW - gambierone

KW - dihydro-44-methylgambierone

KW - dehydroxy-44-methylgambierone

KW - desulfo-hydroxyl gambierone

KW - POLYETHER COMPOUND

KW - DINOFLAGELLATE

KW - DINOPHYCEAE

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DO - 10.3390/md21010003

M3 - RGC 21 - Publication in refereed journal

C2 - 36662176

SN - 1660-3397

VL - 21

JO - Marine Drugs

JF - Marine Drugs

IS - 1

M1 - 3

ER -

Characterization of New Gambierones Produced by Gambierdiscus balechii 1123M1M10

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Research Keywords

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GRF: Investigation of Bioactive Potentials of Benthic and Epiphytic Toxic Algae (BETA) and Their Associated Microbiota

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Characterization of New Gambierones Produced by Gambierdiscus balechii 1123M1M10

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

UN SDGs

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Permanent Link

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GRF: Investigation of Bioactive Potentials of Benthic and Epiphytic Toxic Algae (BETA) and Their Associated Microbiota

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