CEST theranostics: Label-free MR imaging of anticancer drugs

Yuguo Li; Hanwei Chen; Jiadi Xu; Nirbhay N. Yadav; Kannie W. Y. Chan; Liangping Luo; Michael T. McMahon; Bert Vogelstein; Peter C.M. Van Zijl; Shibin Zhou; Guanshu Liu

doi:10.18632/oncotarget.7141

CEST theranostics: Label-free MR imaging of anticancer drugs

Yuguo Li, Hanwei Chen, Jiadi Xu, Nirbhay N. Yadav, Kannie W. Y. Chan, Liangping Luo, Michael T. McMahon, Bert Vogelstein, Peter C.M. Van Zijl, Shibin Zhou, Guanshu Liu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

49 Citations (Scopus)

50 Downloads (CityUHK Scholars)

Abstract

Image-guided drug delivery is of great clinical interest. Here, we explored a direct way, namely CEST theranostics, to detect diamagnetic anticancer drugs simply through their inherent Chemical Exchange Saturation Transfer (CEST) MRI signal, and demonstrated its application in image-guided drug delivery of nanoparticulate chemotherapeutics. We first screened 22 chemotherapeutic agents and characterized the CEST properties of representative agents and natural analogs in three major categories, i.e., pyrimidine analogs, purine analogs, and antifolates, with respect to chemical structures. Utilizing the inherent CEST MRI signal of gemcitabine, a widely used anticancer drug, the tumor uptake of the i.v.-injected, drug-loaded liposomes was successfully detected in CT26 mouse tumors. Such label-free CEST MRI theranostics provides a new imaging means, potentially with an immediate clinical impact, to monitor the drug delivery in cancer.

Original language	English
Pages (from-to)	6369-6378
Journal	Oncotarget
Volume	7
Issue number	6
DOIs	https://doi.org/10.18632/oncotarget.7141
Publication status	Published - 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

CEST
Chemotherapy
Image-guided drug delivery
MRI
Theranostics

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This full text is made available under CC-BY 3.0. https://creativecommons.org/licenses/by/3.0/

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10.18632/oncotarget.7141

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title = "CEST theranostics: Label-free MR imaging of anticancer drugs",

abstract = "Image-guided drug delivery is of great clinical interest. Here, we explored a direct way, namely CEST theranostics, to detect diamagnetic anticancer drugs simply through their inherent Chemical Exchange Saturation Transfer (CEST) MRI signal, and demonstrated its application in image-guided drug delivery of nanoparticulate chemotherapeutics. We first screened 22 chemotherapeutic agents and characterized the CEST properties of representative agents and natural analogs in three major categories, i.e., pyrimidine analogs, purine analogs, and antifolates, with respect to chemical structures. Utilizing the inherent CEST MRI signal of gemcitabine, a widely used anticancer drug, the tumor uptake of the i.v.-injected, drug-loaded liposomes was successfully detected in CT26 mouse tumors. Such label-free CEST MRI theranostics provides a new imaging means, potentially with an immediate clinical impact, to monitor the drug delivery in cancer.",

keywords = "CEST, Chemotherapy, Image-guided drug delivery, MRI, Theranostics",

author = "Yuguo Li and Hanwei Chen and Jiadi Xu and Yadav, {Nirbhay N.} and Chan, {Kannie W. Y.} and Liangping Luo and McMahon, {Michael T.} and Bert Vogelstein and {Van Zijl}, {Peter C.M.} and Shibin Zhou and Guanshu Liu",

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T1 - CEST theranostics

T2 - Label-free MR imaging of anticancer drugs

AU - Li, Yuguo

AU - Chen, Hanwei

AU - Xu, Jiadi

AU - Yadav, Nirbhay N.

AU - Chan, Kannie W. Y.

AU - Luo, Liangping

AU - McMahon, Michael T.

AU - Vogelstein, Bert

AU - Van Zijl, Peter C.M.

AU - Zhou, Shibin

AU - Liu, Guanshu

PY - 2016

Y1 - 2016

N2 - Image-guided drug delivery is of great clinical interest. Here, we explored a direct way, namely CEST theranostics, to detect diamagnetic anticancer drugs simply through their inherent Chemical Exchange Saturation Transfer (CEST) MRI signal, and demonstrated its application in image-guided drug delivery of nanoparticulate chemotherapeutics. We first screened 22 chemotherapeutic agents and characterized the CEST properties of representative agents and natural analogs in three major categories, i.e., pyrimidine analogs, purine analogs, and antifolates, with respect to chemical structures. Utilizing the inherent CEST MRI signal of gemcitabine, a widely used anticancer drug, the tumor uptake of the i.v.-injected, drug-loaded liposomes was successfully detected in CT26 mouse tumors. Such label-free CEST MRI theranostics provides a new imaging means, potentially with an immediate clinical impact, to monitor the drug delivery in cancer.

AB - Image-guided drug delivery is of great clinical interest. Here, we explored a direct way, namely CEST theranostics, to detect diamagnetic anticancer drugs simply through their inherent Chemical Exchange Saturation Transfer (CEST) MRI signal, and demonstrated its application in image-guided drug delivery of nanoparticulate chemotherapeutics. We first screened 22 chemotherapeutic agents and characterized the CEST properties of representative agents and natural analogs in three major categories, i.e., pyrimidine analogs, purine analogs, and antifolates, with respect to chemical structures. Utilizing the inherent CEST MRI signal of gemcitabine, a widely used anticancer drug, the tumor uptake of the i.v.-injected, drug-loaded liposomes was successfully detected in CT26 mouse tumors. Such label-free CEST MRI theranostics provides a new imaging means, potentially with an immediate clinical impact, to monitor the drug delivery in cancer.

KW - CEST

KW - Chemotherapy

KW - Image-guided drug delivery

KW - MRI

KW - Theranostics

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U2 - 10.18632/oncotarget.7141

DO - 10.18632/oncotarget.7141

M3 - RGC 21 - Publication in refereed journal

C2 - 26837220

SN - 1949-2553

VL - 7

SP - 6369

EP - 6378

JO - Oncotarget

JF - Oncotarget

IS - 6

ER -

CEST theranostics: Label-free MR imaging of anticancer drugs

Abstract

UN SDGs

Research Keywords

Publisher's Copyright Statement

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