Projects per year
Abstract
Motivation: The molecular imaging and relationship between the brain and atherosclerosis are poorly understood.
Goal(s): To study the brain during atherosclerosis development and the association of atherosclerosis and brain using CEST MRI.
Approach: 3 months old ApoE –/– and C57BL/6 mouse brains were imaged using 3T preclinical MRI and CEST was applied, then three offsets, 3.5, –1.6 and –3.5 ppm, were extracted for post-processing.
Results: ApoE –/– mouse showed higher APT and rNOE signals than WT in thalamus, hippocampus and cortex, which are associated with neuroinflammation and cholesterol deposition during atherosclerosis development.
Impact: The underlying molecular changes of the brain during atherosclerosis development could enhance the identification of diseases at early stage using CEST MRI.
Goal(s): To study the brain during atherosclerosis development and the association of atherosclerosis and brain using CEST MRI.
Approach: 3 months old ApoE –/– and C57BL/6 mouse brains were imaged using 3T preclinical MRI and CEST was applied, then three offsets, 3.5, –1.6 and –3.5 ppm, were extracted for post-processing.
Results: ApoE –/– mouse showed higher APT and rNOE signals than WT in thalamus, hippocampus and cortex, which are associated with neuroinflammation and cholesterol deposition during atherosclerosis development.
Impact: The underlying molecular changes of the brain during atherosclerosis development could enhance the identification of diseases at early stage using CEST MRI.
| Original language | English |
|---|---|
| Publication status | Published - 9 May 2024 |
| Event | 2024 ISMRM & ISMRT Annual Meeting & Exhibition - Suntec Singapore Convention & Exhibition Centre, Singapore Duration: 4 May 2024 → 9 May 2024 https://www.ismrm.org/24m/ |
Conference
| Conference | 2024 ISMRM & ISMRT Annual Meeting & Exhibition |
|---|---|
| Place | Singapore |
| Period | 4/05/24 → 9/05/24 |
| Internet address |
Bibliographical note
Information for this record is supplemented by the author(s) concerned.Funding
Research Grants Council (11102218, 11200422, RFS2223-1S02, C1134-20G), City University of Hong Kong (7005433, 7005626, 9609307, 9610560 and 9610616), National Natural Science Foundation of China (81871409), Tung Biomedical Sciences Centre and Hong Kong Centre for Cerebro-cardiovascular Health Engineering (COCHE).
Research Keywords
- Atherosclerosis
Fingerprint
Dive into the research topics of 'CEST imaging of ApoE –/– mouse brain during atherosclerosis development'. Together they form a unique fingerprint.-
GRF: Imaging Nose-to-brain Drug Delivery to Brain Tumors Using Multiple CEST MRI Contrast
CHAN, W. Y. K. (Principal Investigator / Project Coordinator) & LEUNG, G. K. K. (Co-Investigator)
1/01/23 → …
Project: Research
-
RFS: Non-invasive CEST MRI Detects Reduced CSF Clearance in the Brain for Early Diagnosis of Alzheimer’s Disease
CHAN, W. Y. K. (Principal Investigator / Project Coordinator)
1/01/23 → …
Project: Research
-
CRF-Sub-pj: A Novel Vaccination Strategy: Using a Microrobot Platform for DNA Vaccine Delivery and Antigen Presentation
CHAN, W. Y. K. (Principal Investigator / Project Coordinator)
1/06/21 → …
Project: Research