CEST effect of dimethyl sulfoxide (DMSO) at negative offset frequency

Haoyun Su; Jianpan Huang; Kannie W.Y. Chan

CEST effect of dimethyl sulfoxide (DMSO) at negative offset frequency

Research output: Conference Papers › RGC 32 - Refereed conference paper (without host publication) › peer-review

Abstract

CEST MRI can detect mM range of endogenous and exogenous molecules, and bound small molecules such as glycogen and lactate via rNOE. Here we reported for the first time that DMSO and its structural analogs in aqueous solution had distinctive CEST peaks at the negative offsets of Z-spectrum. CEST effect of DMSO was dependent on saturation power and concentration, and less sensitive to tested temperature. Alcohols, acetone, acetonitrile, acetic acid and N,N-dimethylformamide also showed observable CEST peaks at the negative offsets. Interaction between DMSO and water molecule, such as hydrogen bonding, could contribute to the observed CEST effect.

Original language	English
Number of pages	2
Publication status	Presented - Jun 2023
Event	2023 ISMRM & ISMRT Annual Meeting & Exhibition - Metro Toronto Convention Centre (MTCC), Toronto, ON, Canada Duration: 3 Jun 2023 → 8 Jun 2023 https://www.ismrm.org/23m/

Meeting

Meeting	2023 ISMRM & ISMRT Annual Meeting & Exhibition
Place	Canada
City	Toronto, ON
Period	3/06/23 → 8/06/23
Internet address	https://www.ismrm.org/23m/

Bibliographical note

Information for this record is supplemented by the author(s) concerned.

Funding

Authors would like to acknowledge the funding supports from Research Grants Council (11102218, PDFS2122-1S01, 11200422, RFS2223-1S02, C1134-20G); City University of Hong Kong (7005433, 7005626, 9239070, 9609307, 9610560); National Natural Science Foundation China (81871409); Tung Biomedical Sciences Centre; Hong Kong Centre for Cerebro-cardiovascular Health Engineering

Research Keywords

CEST & MT
Molecular Imaging

RGC Funding Information

RGC-funded

Permanent Link

Right click to copy link

2 Active
3 Finished

RFS: Non-invasive CEST MRI Detects Reduced CSF Clearance in the Brain for Early Diagnosis of Alzheimer’s Disease
CHAN, W. Y. K. (Principal Investigator / Project Coordinator)
1/01/23 → …
Project: Research
GRF: Imaging Nose-to-brain Drug Delivery to Brain Tumors Using Multiple CEST MRI Contrast
CHAN, W. Y. K. (Principal Investigator / Project Coordinator) & LEUNG, G. K. K. (Co-Investigator)
1/01/23 → …
Project: Research
CRF-Sub-pj: A Novel Vaccination Strategy: Using a Microrobot Platform for DNA Vaccine Delivery and Antigen Presentation
CHAN, W. Y. K. (Principal Investigator / Project Coordinator)
1/06/21 → 31/05/26
Project: Research

2023 ISMRM & ISMRT Annual Meeting & Exhibition
SU, H. (Presenter)
3 Jun 2023 → 8 Jun 2023
Activity: Organizing or Participating in a conference / an event › Conference / Symposium

Cite this

@conference{d8262ef416f949f3b6e710d87b63f2f5,

title = "CEST effect of dimethyl sulfoxide (DMSO) at negative offset frequency",

abstract = "CEST MRI can detect mM range of endogenous and exogenous molecules, and bound small molecules such as glycogen and lactate via rNOE. Here we reported for the first time that DMSO and its structural analogs in aqueous solution had distinctive CEST peaks at the negative offsets of Z-spectrum. CEST effect of DMSO was dependent on saturation power and concentration, and less sensitive to tested temperature. Alcohols, acetone, acetonitrile, acetic acid and N,N-dimethylformamide also showed observable CEST peaks at the negative offsets. Interaction between DMSO and water molecule, such as hydrogen bonding, could contribute to the observed CEST effect.",

keywords = "CEST \& MT, Molecular Imaging",

author = "Haoyun Su and Jianpan Huang and Chan, \{Kannie W.Y.\}",

note = "Information for this record is supplemented by the author(s) concerned.; 2023 ISMRM \& ISMRT Annual Meeting \& Exhibition ; Conference date: 03-06-2023 Through 08-06-2023",

year = "2023",

month = jun,

language = "English",

url = "https://www.ismrm.org/23m/",

}

TY - CONF

T1 - CEST effect of dimethyl sulfoxide (DMSO) at negative offset frequency

AU - Su, Haoyun

AU - Huang, Jianpan

AU - Chan, Kannie W.Y.

N1 - Information for this record is supplemented by the author(s) concerned.

PY - 2023/6

Y1 - 2023/6

N2 - CEST MRI can detect mM range of endogenous and exogenous molecules, and bound small molecules such as glycogen and lactate via rNOE. Here we reported for the first time that DMSO and its structural analogs in aqueous solution had distinctive CEST peaks at the negative offsets of Z-spectrum. CEST effect of DMSO was dependent on saturation power and concentration, and less sensitive to tested temperature. Alcohols, acetone, acetonitrile, acetic acid and N,N-dimethylformamide also showed observable CEST peaks at the negative offsets. Interaction between DMSO and water molecule, such as hydrogen bonding, could contribute to the observed CEST effect.

AB - CEST MRI can detect mM range of endogenous and exogenous molecules, and bound small molecules such as glycogen and lactate via rNOE. Here we reported for the first time that DMSO and its structural analogs in aqueous solution had distinctive CEST peaks at the negative offsets of Z-spectrum. CEST effect of DMSO was dependent on saturation power and concentration, and less sensitive to tested temperature. Alcohols, acetone, acetonitrile, acetic acid and N,N-dimethylformamide also showed observable CEST peaks at the negative offsets. Interaction between DMSO and water molecule, such as hydrogen bonding, could contribute to the observed CEST effect.

KW - CEST & MT

KW - Molecular Imaging

M3 - RGC 32 - Refereed conference paper (without host publication)

T2 - 2023 ISMRM & ISMRT Annual Meeting & Exhibition

Y2 - 3 June 2023 through 8 June 2023

ER -

CEST effect of dimethyl sulfoxide (DMSO) at negative offset frequency

Abstract

Meeting

Bibliographical note

Funding

Research Keywords

RGC Funding Information

Permanent Link

Fingerprint

Projects

RFS: Non-invasive CEST MRI Detects Reduced CSF Clearance in the Brain for Early Diagnosis of Alzheimer’s Disease

GRF: Imaging Nose-to-brain Drug Delivery to Brain Tumors Using Multiple CEST MRI Contrast

CRF-Sub-pj: A Novel Vaccination Strategy: Using a Microrobot Platform for DNA Vaccine Delivery and Antigen Presentation

Activities

2023 ISMRM & ISMRT Annual Meeting & Exhibition

Cite this