CEST and MISL detect regional neuropathologies in a Parkinson’s disease mouse model at 3T

Research output: Conference PapersAbstractpeer-review

View graph of relations

Detail(s)

Original languageEnglish
Publication statusPublished - Jun 2023

Conference

Title2023 International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2023)
LocationMetro Toronto Convention Centre (MTCC)
PlaceCanada
CityToronto
Period3 - 8 June 2023

Abstract

Reveal alterations in molecules and CSF-tissue water exchange could enable interactive interventions in PD. Here we applied CEST and MISL to study the changes in a PD model at 3T. We observed significant changes (P<0.05) at 2.6ppm on day 28 and at -3.5ppm on day 7, which could indicate a substantial decrease of dopamine and lipid-related pathology at the substantia nigra, respectively. Along the nigrostriatal pathway, we observed a gradual MISL drop at the ventricles, which was significantly lower at day 28 (P<0.05) and might imply the CSF-tissue-related pathologies. Our findings could serve as potential biomarkers for early PD detection.

Research Area(s)

  • Parkinson's Disease, CEST & MT

Citation Format(s)

CEST and MISL detect regional neuropathologies in a Parkinson’s disease mouse model at 3T. / Lai, Joseph H. C.; Huang, Jianpan; Liu, Yang et al.
2023. Abstract from 2023 International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2023), Toronto, Ontario, Canada.

Research output: Conference PapersAbstractpeer-review