CEST and MISL detect regional neuropathologies in a Parkinson’s disease mouse model at 3T
Research output: Conference Papers › Abstract › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
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Publication status | Published - Jun 2023 |
Conference
Title | 2023 International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2023) |
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Location | Metro Toronto Convention Centre (MTCC) |
Place | Canada |
City | Toronto |
Period | 3 - 8 June 2023 |
Link(s)
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(3777392b-1ed8-45fe-8ffc-5fba230d2ca0).html |
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Abstract
Reveal alterations in molecules and CSF-tissue water exchange could enable interactive interventions in PD. Here we applied CEST and MISL to study the changes in a PD model at 3T. We observed significant changes (P<0.05) at 2.6ppm on day 28 and at -3.5ppm on day 7, which could indicate a substantial decrease of dopamine and lipid-related pathology at the substantia nigra, respectively. Along the nigrostriatal pathway, we observed a gradual MISL drop at the ventricles, which was significantly lower at day 28 (P<0.05) and might imply the CSF-tissue-related pathologies. Our findings could serve as potential biomarkers for early PD detection.
Research Area(s)
- Parkinson's Disease, CEST & MT
Citation Format(s)
CEST and MISL detect regional neuropathologies in a Parkinson’s disease mouse model at 3T. / Lai, Joseph H. C.; Huang, Jianpan; Liu, Yang et al.
2023. Abstract from 2023 International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2023), Toronto, Ontario, Canada.
2023. Abstract from 2023 International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2023), Toronto, Ontario, Canada.
Research output: Conference Papers › Abstract › peer-review