CEST and MISL detect regional neuropathologies in a Parkinson’s disease mouse model at 3T

Joseph H. C. Lai; Jianpan Huang; Yang Liu; Se Weon Park; Jiadi Xu; Kannie W. Y. Chan

CEST and MISL detect regional neuropathologies in a Parkinson’s disease mouse model at 3T

Joseph H. C. Lai, Jianpan Huang, Yang Liu, Se Weon Park, Jiadi Xu, Kannie W. Y. Chan^*

^*Corresponding author for this work

Research output: Conference Papers › Abstract › peer-review

Abstract

Reveal alterations in molecules and CSF-tissue water exchange could enable interactive interventions in PD. Here we applied CEST and MISL to study the changes in a PD model at 3T. We observed significant changes (P<0.05) at 2.6ppm on day 28 and at -3.5ppm on day 7, which could indicate a substantial decrease of dopamine and lipid-related pathology at the substantia nigra, respectively. Along the nigrostriatal pathway, we observed a gradual MISL drop at the ventricles, which was significantly lower at day 28 (P<0.05) and might imply the CSF-tissue-related pathologies. Our findings could serve as potential biomarkers for early PD detection.

Original language	English
Publication status	Published - Jun 2023
Event	2023 International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2023) - Metro Toronto Convention Centre (MTCC), Toronto, Canada Duration: 3 Jun 2023 → 8 Jun 2023 https://www.ismrm.org/23m/

Conference

Conference	2023 International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2023)
Abbreviated title	ISMRM Annual Meeting & Exhibition 2023
Place	Canada
City	Toronto
Period	3/06/23 → 8/06/23
Internet address	https://www.ismrm.org/23m/

Research Keywords

Parkinson's Disease
CEST & MT

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@conference{3777392b1ed845fe8ffc5fba230d2ca0,

title = "CEST and MISL detect regional neuropathologies in a Parkinson{\textquoteright}s disease mouse model at 3T",

abstract = "Reveal alterations in molecules and CSF-tissue water exchange could enable interactive interventions in PD. Here we applied CEST and MISL to study the changes in a PD model at 3T. We observed significant changes (P<0.05) at 2.6ppm on day 28 and at -3.5ppm on day 7, which could indicate a substantial decrease of dopamine and lipid-related pathology at the substantia nigra, respectively. Along the nigrostriatal pathway, we observed a gradual MISL drop at the ventricles, which was significantly lower at day 28 (P<0.05) and might imply the CSF-tissue-related pathologies. Our findings could serve as potential biomarkers for early PD detection.",

keywords = "Parkinson's Disease, CEST & MT",

author = "Lai, {Joseph H. C.} and Jianpan Huang and Yang Liu and Park, {Se Weon} and Jiadi Xu and Chan, {Kannie W. Y.}",

year = "2023",

month = jun,

language = "English",

note = "2023 International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2023), ISMRM Annual Meeting & Exhibition 2023 ; Conference date: 03-06-2023 Through 08-06-2023",

url = "https://www.ismrm.org/23m/",

}

TY - CONF

T1 - CEST and MISL detect regional neuropathologies in a Parkinson’s disease mouse model at 3T

AU - Lai, Joseph H. C.

AU - Huang, Jianpan

AU - Liu, Yang

AU - Park, Se Weon

AU - Xu, Jiadi

AU - Chan, Kannie W. Y.

PY - 2023/6

Y1 - 2023/6

N2 - Reveal alterations in molecules and CSF-tissue water exchange could enable interactive interventions in PD. Here we applied CEST and MISL to study the changes in a PD model at 3T. We observed significant changes (P<0.05) at 2.6ppm on day 28 and at -3.5ppm on day 7, which could indicate a substantial decrease of dopamine and lipid-related pathology at the substantia nigra, respectively. Along the nigrostriatal pathway, we observed a gradual MISL drop at the ventricles, which was significantly lower at day 28 (P<0.05) and might imply the CSF-tissue-related pathologies. Our findings could serve as potential biomarkers for early PD detection.

AB - Reveal alterations in molecules and CSF-tissue water exchange could enable interactive interventions in PD. Here we applied CEST and MISL to study the changes in a PD model at 3T. We observed significant changes (P<0.05) at 2.6ppm on day 28 and at -3.5ppm on day 7, which could indicate a substantial decrease of dopamine and lipid-related pathology at the substantia nigra, respectively. Along the nigrostriatal pathway, we observed a gradual MISL drop at the ventricles, which was significantly lower at day 28 (P<0.05) and might imply the CSF-tissue-related pathologies. Our findings could serve as potential biomarkers for early PD detection.

KW - Parkinson's Disease

KW - CEST & MT

M3 - Abstract

T2 - 2023 International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2023)

Y2 - 3 June 2023 through 8 June 2023

ER -

CEST and MISL detect regional neuropathologies in a Parkinson’s disease mouse model at 3T

Abstract

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