Cervicovaginal Microbiome Factors in Clearance of Human Papillomavirus Infection
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
| Original language | English |
|---|---|
| Article number | 722639 |
| Journal / Publication | Frontiers in Oncology |
| Volume | 11 |
| Online published | 28 Jul 2021 |
| Publication status | Published - Jul 2021 |
Link(s)
| DOI | DOI |
|---|---|
| Attachment(s) | Documents
Publisher's Copyright Statement
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| Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85112341947&origin=recordpage |
| Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(dda9f2e4-e64c-429f-93e8-aecbf895a5ba).html |
Abstract
Persistent high-risk human papillomavirus (hrHPV) infection is the highest risk to cervical cancer which is the fourth most common cancer in women worldwide. A growing body of literatures demonstrate the role of cervicovaginal microbiome (CVM) in hrHPV susceptibility and clearance, suggesting the promise of CVM-targeted interventions in protecting against or eliminating HPV infection. Nevertheless, the CVM-HPV-host interactions are largely unknown. In this review, we summarize imbalanced CVM in HPV-positive women, with or without cervical diseases, and the progress of exploring CVM resources in HPV clearance. In addition, microbe- and host-microbe interactions in HPV infection and elimination are reviewed to understand the role of CVM in remission of HPV infection. Lastly, the feasibility of CVM-modulated and -derived products in promoting HPV clearance is discussed. Information in this article will provide valuable reference for researchers interested in cervical cancer prevention and therapy.
Research Area(s)
- cervical cancer, CVM-derived product, CVM-targeted intervention, high-risk HPV, HPV clearance
Citation Format(s)
Cervicovaginal Microbiome Factors in Clearance of Human Papillomavirus Infection. / Dai, Wenkui; Du, Hui; Li, Shuaicheng et al.
In: Frontiers in Oncology, Vol. 11, 722639, 07.2021.
In: Frontiers in Oncology, Vol. 11, 722639, 07.2021.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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