Cellular response to nano-structured Zr and ZrO2 alloyed layers on Ti-6Al-4V

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Xiangyu Zhang
  • Guannan Zhang
  • Jianfang Li
  • Xiaojing He
  • Yueyue Wang
  • Ruiqiang Hang
  • Xiaobo Huang
  • Bin Tang

Detail(s)

Original languageEnglish
Pages (from-to)523-530
Journal / PublicationMaterials Science and Engineering C
Volume90
Online published3 May 2018
Publication statusPublished - 1 Sept 2018

Abstract

The surface topography of biomaterials is known to influence cellular response such as adhesion, spreading and differentiation. In this work, the behavior of osteoblasts and endothelial cells on nano-structured Zr and micro/nano-structured ZrO2 alloyed layers of Ti-6Al-4V (TC4) was investigated. Zr alloyed layer (Zr@TC4) decreases the hydrophilicity whereas ZrO2 alloyed layers (ZrO2@TC4) is more hydrophilic than TC4 and more proteins adsorb on ZrO2@TC4 followed by Zr@TC4. The cells proliferate steadily on the smooth TC4 and nano-structured Zr@TC4 surfaces and the osteoblast activity is more pronounced on Zr@TC4 than TC4. The micro/nano-structured surface on ZrO2@TC4 restricts cellular adhesion and spreading independent of the surface wettability and protein adsorption. The findings provide insights into the design of micro/nano-structured biomaterials and interfaces with controlled tissue response.

Research Area(s)

  • Biomaterials, Cell adhesion, Cell survival, Surface topography

Citation Format(s)

Cellular response to nano-structured Zr and ZrO2 alloyed layers on Ti-6Al-4V. / Zhang, Xiangyu; Zhang, Guannan; Li, Jianfang et al.
In: Materials Science and Engineering C, Vol. 90, 01.09.2018, p. 523-530.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review