Cellular response to nano-structured Zr and ZrO2 alloyed layers on Ti-6Al-4V

Xiangyu Zhang; Guannan Zhang; Jianfang Li; Xiaojing He; Yueyue Wang; Ruiqiang Hang; Xiaobo Huang; Bin Tang; Paul K. Chu

doi:10.1016/j.msec.2018.05.009

Author(s)

Xiangyu Zhang
Guannan Zhang
Jianfang Li
Xiaojing He
Yueyue Wang
Ruiqiang Hang
Xiaobo Huang
Bin Tang

Detail(s)

Original language	English
Pages (from-to)	523-530
Journal / Publication	Materials Science and Engineering C
Volume	90
Online published	3 May 2018
Publication status	Published - 1 Sept 2018

Link(s)

DOI	DOI https://doi.org/10.1016/j.msec.2018.05.009 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85046681881&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(96762e99-12e9-4830-a072-aad0e20ffd02).html

Abstract

The surface topography of biomaterials is known to influence cellular response such as adhesion, spreading and differentiation. In this work, the behavior of osteoblasts and endothelial cells on nano-structured Zr and micro/nano-structured ZrO₂ alloyed layers of Ti-6Al-4V (TC4) was investigated. Zr alloyed layer (Zr@TC4) decreases the hydrophilicity whereas ZrO₂ alloyed layers (ZrO₂@TC4) is more hydrophilic than TC4 and more proteins adsorb on ZrO₂@TC4 followed by Zr@TC4. The cells proliferate steadily on the smooth TC4 and nano-structured Zr@TC4 surfaces and the osteoblast activity is more pronounced on Zr@TC4 than TC4. The micro/nano-structured surface on ZrO₂@TC4 restricts cellular adhesion and spreading independent of the surface wettability and protein adsorption. The findings provide insights into the design of micro/nano-structured biomaterials and interfaces with controlled tissue response.

Research Area(s)

Biomaterials, Cell adhesion, Cell survival, Surface topography

Citation Format(s)

[ RIS ] [ BibTeX ]

Cellular response to nano-structured Zr and ZrO₂ alloyed layers on Ti-6Al-4V. / Zhang, Xiangyu; Zhang, Guannan; Li, Jianfang et al.
In: Materials Science and Engineering C, Vol. 90, 01.09.2018, p. 523-530.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Zhang, X, Zhang, G, Li, J, He, X, Wang, Y, Hang, R, Huang, X, Tang, B & Chu, PK 2018, 'Cellular response to nano-structured Zr and ZrO₂ alloyed layers on Ti-6Al-4V', Materials Science and Engineering C, vol. 90, pp. 523-530. https://doi.org/10.1016/j.msec.2018.05.009

Zhang, X., Zhang, G., Li, J., He, X., Wang, Y., Hang, R., Huang, X., Tang, B., & Chu, P. K. (2018). Cellular response to nano-structured Zr and ZrO₂ alloyed layers on Ti-6Al-4V. Materials Science and Engineering C, 90, 523-530. https://doi.org/10.1016/j.msec.2018.05.009

Zhang X, Zhang G, Li J, He X, Wang Y, Hang R et al. Cellular response to nano-structured Zr and ZrO₂ alloyed layers on Ti-6Al-4V. Materials Science and Engineering C. 2018 Sept 1;90:523-530. Epub 2018 May 3. doi: 10.1016/j.msec.2018.05.009

Zhang, Xiangyu ; Zhang, Guannan ; Li, Jianfang et al. / Cellular response to nano-structured Zr and ZrO₂ alloyed layers on Ti-6Al-4V. In: Materials Science and Engineering C. 2018 ; Vol. 90. pp. 523-530.