Cell-borne 2D nanomaterials for efficient cancer targeting and photothermal therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

36 Scopus Citations
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Author(s)

  • Zhibin Li
  • Jundong Shao
  • Qian Luo
  • Xue-Feng Yu
  • Hanhan Xie
  • Haidi Fu
  • Siying Tang
  • Huaiyu Wang
  • Guangli Han

Detail(s)

Original languageEnglish
Pages (from-to)37-48
Journal / PublicationBiomaterials
Volume133
Publication statusPublished - 1 Jul 2017

Abstract

Two of the challenges for clinical implementation of nano-therapeutic strategies are optimization of tumor targeting and clearance of the nanoagents in vivo. Herein, a cell-mediated therapy by transporting 2D Bi2Se3 nanosheets within macrophage vehicles is described. The Bi2Se3 nanosheets with excellent near-infrared photothermal performance exhibit high macrophage uptake and negligible cytotoxicity thus facilitating the fabrication of Bi2Se3-laden-macrophages. Compared with bare Bi2Se3, the Bi2Se3-laden-macrophages after intravenous injection show prolonged blood circulation and can overcome the hypoxia-associated drug delivery barrier to target the tumor efficiently and dramatically enhance the efficiency of photothermal cancer therapy. The Bi2Se3-laden-macrophages possess good biocompatibility as demonstrated by the biochemical and histological analyses and furthermore, most of the materials are excreted from the body within 25 days. Our findings reveal a desirable system for highly efficient near-infrared photothermal cancer therapy.

Research Area(s)

  • 2D nanomaterials, Bi2Se3 nanosheets, Drug delivery, Near-infrared, Photothermal therapy

Citation Format(s)

Cell-borne 2D nanomaterials for efficient cancer targeting and photothermal therapy. / Li, Zhibin; Shao, Jundong; Luo, Qian; Yu, Xue-Feng; Xie, Hanhan; Fu, Haidi; Tang, Siying; Wang, Huaiyu; Han, Guangli; Chu, Paul K.

In: Biomaterials, Vol. 133, 01.07.2017, p. 37-48.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal