Cell-based drug screening on microfluidics

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

48 Scopus Citations
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Author(s)

  • Jiao Zhai
  • Shuhong Yi
  • Yanwei Jia
  • Pui-In Mak
  • Rui P. Martins

Detail(s)

Original languageEnglish
Pages (from-to)231-241
Journal / PublicationTrAC - Trends in Analytical Chemistry
Volume117
Online published20 May 2019
Publication statusPublished - Aug 2019
Externally publishedYes

Abstract

With the inherent merits of a low reagent consumption, the small amount of sample needed and easy integration, a wide variety of microfluidic platforms (continuous-flow, droplet, digital and paper) have been developed to address the challenges (e.g. throughput, single-cell isolation, cost and flexibility) of cell-based drug screening. This review essentially summarises the pros and cons of the platforms for different applications, so as to shed light on the road ahead for drug screening research and discovery via the advance of microfluidics. © 2019 Elsevier B.V. All rights reserved.

Research Area(s)

  • 3D cell-based drug screening, Continuous-flow based microfluidics, Digital microfluidics, Droplet microfluidics, High-throughput drug screening, Paper microfluidics, Sing cell drug screening

Citation Format(s)

Cell-based drug screening on microfluidics. / Zhai, Jiao; Yi, Shuhong; Jia, Yanwei et al.
In: TrAC - Trends in Analytical Chemistry, Vol. 117, 08.2019, p. 231-241.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review