Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. I. Taxonomy and fermentation

D. Abbanat; M. Leighton; W. Maiese; E. B.G. Jones; C. Pearce; M. Greenstein

doi:10.7164/antibiotics.51.296

Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. I. Taxonomy and fermentation

D. Abbanat
, M. Leighton
, W. Maiese
, E. B.G. Jones
, C. Pearce
, M. Greenstein

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

50 Citations (Scopus)

Abstract

The cell wall targeted antifungal activity of Hypoxylon oceanicum LL-15G256 extracts resulted from the production of novel lipodepsipeptides and previously reported macrocyclic polylactones. In an optimized medium, titers of the lipodepsipeptide and the polylactones reached approximately 200~400 mg/liter and 25~50 mg/liter, respectively. The optimum fermentation temperature for production of 15G256γ was 28°C. Seawater appeared to have an inhibitory effect on metabolite accumulation at lower fermentation temperatures.
© Japan Antibiotics Research Association

Original language	English
Pages (from-to)	296-302
Journal	Journal of Antibiotics
Volume	51
Issue number	3
DOIs	https://doi.org/10.7164/antibiotics.51.296
Publication status	Published - Mar 1998
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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title = "Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. I. Taxonomy and fermentation",

abstract = "The cell wall targeted antifungal activity of Hypoxylon oceanicum LL-15G256 extracts resulted from the production of novel lipodepsipeptides and previously reported macrocyclic polylactones. In an optimized medium, titers of the lipodepsipeptide and the polylactones reached approximately 200\textasciitilde{}400 mg/liter and 25\textasciitilde{}50 mg/liter, respectively. The optimum fermentation temperature for production of 15G256γ was 28°C. Seawater appeared to have an inhibitory effect on metabolite accumulation at lower fermentation temperatures. {\textcopyright} Japan Antibiotics Research Association",

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AU - Abbanat, D.

AU - Leighton, M.

AU - Maiese, W.

AU - Jones, E. B.G.

AU - Pearce, C.

AU - Greenstein, M.

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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AB - The cell wall targeted antifungal activity of Hypoxylon oceanicum LL-15G256 extracts resulted from the production of novel lipodepsipeptides and previously reported macrocyclic polylactones. In an optimized medium, titers of the lipodepsipeptide and the polylactones reached approximately 200~400 mg/liter and 25~50 mg/liter, respectively. The optimum fermentation temperature for production of 15G256γ was 28°C. Seawater appeared to have an inhibitory effect on metabolite accumulation at lower fermentation temperatures. © Japan Antibiotics Research Association

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JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 3

ER -

Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. I. Taxonomy and fermentation

Abstract

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