Cell Chiral Orientation Enhanced by Intercellular Alignment
Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
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Title of host publication | Proceedings of the 12th IEEE International Conference on Nano/Molecular Medicine and Engineering |
Publisher | Institute of Electrical and Electronics Engineers, Inc. |
Pages | 104-108 |
ISBN (electronic) | 978-1-5386-7579-3 |
Publication status | Published - Dec 2018 |
Publication series
Name | IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED |
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Volume | 2018-December |
ISSN (Print) | 2159-6964 |
ISSN (electronic) | 2159-6972 |
Conference
Title | 12th IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED 2018) |
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Place | United States |
City | Waikiki Beach |
Period | 2 - 5 December 2018 |
Link(s)
Abstract
Cells exhibit chiral orientation on micropatterned stripes, which reflects the development of left-right (LR) asymmetry in tissue microarchitecture. We previously reported a dependence of cell chirality on substrate stiffness, as more cells oriented with negative angles on glass but not on PDMS substrate. However, the mechanism remains unclear. Here, using an image processing method which automates segmentation of individual nucleus, we found that enhanced chirality correlates with an increased intercellular alignment on glass substrate. More interestingly, comparing image with low cell density (< 50,000 cells/cm2 ) to high cell density (> 180,000 cells/cm2 ), the increased cell density does not improve the intercellular alignment but only reduces the distance between neighbouring cells, making the chirality independent of density range of tests.
Citation Format(s)
Cell Chiral Orientation Enhanced by Intercellular Alignment. / Kwong, Hoi Kwan; Huang, Yaozhun; Bao, Yuanye et al.
Proceedings of the 12th IEEE International Conference on Nano/Molecular Medicine and Engineering. Institute of Electrical and Electronics Engineers, Inc., 2018. p. 104-108 8641654 (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED; Vol. 2018-December).
Proceedings of the 12th IEEE International Conference on Nano/Molecular Medicine and Engineering. Institute of Electrical and Electronics Engineers, Inc., 2018. p. 104-108 8641654 (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED; Vol. 2018-December).
Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review