Cell behaviors mediated by the scale of extracellular matrix micro-islands

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review

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Detail(s)

Original languageEnglish
Title of host publicationIEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
PublisherIEEE Computer Society
Pages65-68
ISBN (Print)9781509046751
Publication statusPublished - 20 Mar 2017

Publication series

Name
ISSN (Print)2159-6964
ISSN (Electronic)2159-6972

Conference

Title10th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2016
PlaceChina
CityMacau
Period30 October - 2 November 2016

Abstract

Extracellular matrix (ECM) plays a critical role in regulating cell behaviors such as proliferation, spreading, migration and differentiation. Here we investigate ECM micro-patterns as a factor of cell-ECM interactions. Different sizes of circular ECM islands were fabricated using the microcontact printing (μCP) technique as an array of cell attachment sites spreading over the substrates. We investigate the scale of ECM islands on their effects on cell morphology and the focal adhesions (FAs) characteristics. Further, we observe morphological changes and cytoskeleton formation during the cell spreading stage of cells on different ECM patterns, revealing that the size and gap distance between the patterns influences the cell spreading as well as the dynamic cytoskeleton architecture significantly.

Citation Format(s)

Cell behaviors mediated by the scale of extracellular matrix micro-islands. / Hu, Shuhuan; Lam, Raymond H.W.

IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED. IEEE Computer Society, 2017. p. 65-68 7883489.

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review