Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

22 Scopus Citations
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Author(s)

  • Zhuoyi Liang
  • Tao Ye
  • Xiaopu Zhou
  • Amy K. Y. Fu
  • Nancy Y. Ip

Detail(s)

Original languageEnglish
Pages (from-to)15127-15134
Journal / PublicationJournal of Neuroscience
Volume35
Issue number45
Publication statusPublished - 11 Nov 2015
Externally publishedYes

Link(s)

Abstract

The proper growth and arborization of dendrites in response to sensory experience are essential for neural connectivity and information processing in the brain. Although neuronal activity is important for sculpting dendrite morphology, the underlying molecular mechanisms are not well understood. Here, we report that cyclin-dependent kinase 5 (Cdk5)-mediated transcriptional regulation is a key mechanism that controls activity-dependent dendrite development in cultured rat neurons. During membrane depolarization, Cdk5 accumulates in the nucleus to regulate the expression of a subset of genes, including that of the neurotrophin brain-derived neurotrophic factor, for subsequent dendritic growth. Furthermore, Cdk5 function is mediated through the phosphorylation of methyl-CpG-binding protein 2, a key transcriptional repressor that is mutated in the mental disorder Rett syndrome. These findings collectively suggest that the nuclear import of Cdk5 is crucial for activity-dependent dendrite development by regulating neuronal gene transcription during neural development.

Research Area(s)

  • BDNF, Dendrite, MeCP2, Neurotrophin, Nuclear translocation, Transcription

Citation Format(s)

Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development. / Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok-On; Fu, Amy K. Y.; Ip, Nancy Y.

In: Journal of Neuroscience, Vol. 35, No. 45, 11.11.2015, p. 15127-15134.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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