CD36 favours fat sensing and transport to govern lipid metabolism

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

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Author(s)

  • Yunxia Li
  • Xingguo Huang
  • Kang Xu
  • Yulong Yin
  • Gabriele Brecchia
  • Jie Yin

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number101193
Journal / PublicationProgress in Lipid Research
Volume88
Online published31 Aug 2022
Publication statusPublished - Nov 2022

Link(s)

DOI

DOI
Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-85138586501&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(89676dfc-a832-4b2d-bfa6-09db3b5b07ec).html

Abstract

CD36, located on the cell membrane, transports fatty acids in response to dietary fat. It is a critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 and lipid dysmetabolism and obesity has been identified in various models and human studies. Nevertheless, the mechanisms by which CD36 regulates lipid metabolism and the role of CD36 in metabolic diseases remain obscure. Here, we summarize the latest research on the role of membrane CD36 in fat metabolism, with emphasis on CD36-mediated fat sensing and transport. This review also critically discusses the factors affecting the regulation of CD36-mediated fat dysfunction. Finally, we review previous clinical evidence of CD36 in metabolic diseases and consider the path forward.

Research Area(s)

  • CD36, Fatty acids, Lipid dysmetabolism, Lipid sensing, Lipid transport, Obesity

Citation Format(s)

[ RIS ] [ BibTeX ]
CD36 favours fat sensing and transport to govern lipid metabolism. / Li, Yunxia; Huang, Xingguo; Yang, Guan et al.
In: Progress in Lipid Research, Vol. 88, 101193, 11.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review