Cationic Alternating Polypeptide Fixed on Polyurethane at Multiple Sites for Excellent Antibacterial and Antifouling Properties

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Fuqiang Liu
  • Wei Qu
  • Jie Zhang
  • Jun Liu
  • Qiongqiong Zhu
  • Ting Yue
  • Xiangmei Xu
  • Nan Ma
  • Junhui Ma
  • Yifan Sun
  • Yan Tang
  • Wei Zhang

Detail(s)

Original languageEnglish
Pages (from-to)10657–10667
Journal / PublicationLangmuir
Volume37
Issue number36
Online published27 Aug 2021
Publication statusPublished - 14 Sep 2021

Abstract

Bacterial infection and blockage are severe problems for polyurethane (PU) catheters and there is an urgent demand for surface-functionalized polyurethane. Herein, a cationic alternating copolymer comprising allyl-substituted ornithine and glycine (allyl-substituted poly(Orn-alter-Gly)) with abundant carbon-carbon double bond functional groups (C═C) is designed. Polyurethane is prepared with a large quantity of C═C groups (PU-D), and different amounts of allyl-substituted poly(Orn-alter-Gly) are grafted onto the PU-D surface (PU-D-2%AMPs and PU-D-20%AMPs) via the C═C functional groups. The chemical structures of the allyl-substituted poly(Orn-alter-Gly) and polyurethane samples (PU, PU-D, PU-D-2%AMPs, and PU-D-20%AMPs) are characterized and the results reveal that allyl-substituted poly(Orn-alter-Gly) is decorated on the polyurethane. PU-D-20%AMPs shows excellent antibacterial activity against Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus because of the high surface potential caused by cationic allyl-substituted poly(Orn-alter-Gly), and it also exhibits excellent long-term antibacterial activity and antibiofilm properties. PU-D-20%AMPs also has excellent antifouling properties because the cationic copolymer is fixed at multiple reactive sites, thus avoiding the formation of movable long chain brush. A strong surface hydration barrier is also formed to prevent adsorption of proteins and ions, and in vivo experiments reveal excellent biocompatibility. This flexible strategy to prepare dual-functional polyurethane surfaces with antibacterial and antifouling properties has large potential in biomedical implants.

Citation Format(s)

Cationic Alternating Polypeptide Fixed on Polyurethane at Multiple Sites for Excellent Antibacterial and Antifouling Properties. / Liu, Fuqiang; Qu, Wei; Zhang, Jie; Liu, Jun; Zhu, Qiongqiong; Yue, Ting; Xu, Xiangmei; Ma, Nan; Ma, Junhui; Sun, Yifan; Tang, Yan; Zhang, Wei; Chu, Paul K.

In: Langmuir, Vol. 37, No. 36, 14.09.2021, p. 10657–10667.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review