Abstract
A palladium/norbornene cocatalyzed three-component reaction of aryl iodides, O-benzoylhydroxylamines, and acetone is reported. o′-Aminoaryl acetones or o,o′-diaminoaryl acetones are efficiently prepared via tandem ortho-C-H amination/ipso-C-I α-arylation sequence, and the regiospecificity has been confirmed by X-ray analysis. The proposed method addresses the condensation/amination of free-N-H-bearing substrates in acetone monoarylations and the synthesis of extremely congested 2,6-disubstituted aryl acetones. © 2017 American Chemical Society.
| Original language | English |
|---|---|
| Pages (from-to) | 4335-4338 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 19 |
| Issue number | 16 |
| Online published | 31 Jul 2017 |
| DOIs | |
| Publication status | Published - 18 Aug 2017 |
| Externally published | Yes |
Funding
We thank RGC of Hong Kong (GRF: 153367/16P; CRF: C5023-14G; and PolyU11/CRF/13E [X-ray equipment]) for financial support. National Natural Science Foundation of China (Grant No. 21602172) is gratefully acknowledged.
RGC Funding Information
- RGC-funded
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