Cartilage Tissue Engineering in Practice: Preclinical Trials, Clinical Applications, and Prospects

Zhen Zhang; Yulei Mu; Huiqun Zhou; Hang Yao; Dong-An Wang

doi:10.1089/ten.teb.2022.0190

Cartilage Tissue Engineering in Practice: Preclinical Trials, Clinical Applications, and Prospects

Zhen Zhang
, Yulei Mu
, Huiqun Zhou
, Hang Yao^*
, Dong-An Wang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

13 Citations (Scopus)

Abstract

Articular cartilage defects significantly compromise the quality of life in the global population. Although many strategies are needed to repair articular cartilage, including microfracture, autologous osteochondral transplantation, and osteochondral allograft, the therapeutic effects remain suboptimal. In recent years, with the development of cartilage tissue engineering, scientists have continuously improved the formulations of therapeutic cells, biomaterial-based scaffolds, and biological factors, which have opened new avenues for better therapeutics of cartilage lesions. This review focuses on advances in cartilage tissue engineering, particularly in preclinical trials and clinical applications, prospects, and challenges.
© 2023, Mary Ann Liebert, Inc.

Original language	English
Pages (from-to)	473-490
Journal	Tissue Engineering - Part B: Reviews
Volume	29
Issue number	5
Online published	2 May 2023
DOIs	https://doi.org/10.1089/ten.teb.2022.0190
Publication status	Published - 12 Oct 2023

Funding

This work was supported by General Research Fund, Research Grants Council, University Grants Committee, Hong Kong SAR (CityU 11205520); National Natural Science Foundation of China (NSFC51973180); Grant from Karolinska Institute Ming Wai Lau Centre of Reparative Medicine (to Dong-An Wang); Grants from City University of Hong Kong (7020028, 9231412, 9678192); and Young scientists lifting project of Jiangsu Province, China (TJ-2022-072 to Hang Yao).

Research Keywords

articular cartilage
tissue engineering
preclinical
clinical
biomaterials
AUTOLOGOUS CHONDROCYTE IMPLANTATION
PLURIPOTENT STEM-CELLS
INTERPENETRATING-NETWORK HYDROGEL
BILAYER COLLAGEN MEMBRANE
MESENCHYMAL STROMAL CELLS
ARTICULAR-CARTILAGE
IN-VITRO
FOLLOW-UP
OSTEOCHONDRAL DEFECTS
EXTRACELLULAR-MATRIX

RGC Funding Information

RGC-funded

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10.1089/ten.teb.2022.0190

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Check CityUHK Library

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title = "Cartilage Tissue Engineering in Practice: Preclinical Trials, Clinical Applications, and Prospects",

abstract = "Articular cartilage defects significantly compromise the quality of life in the global population. Although many strategies are needed to repair articular cartilage, including microfracture, autologous osteochondral transplantation, and osteochondral allograft, the therapeutic effects remain suboptimal. In recent years, with the development of cartilage tissue engineering, scientists have continuously improved the formulations of therapeutic cells, biomaterial-based scaffolds, and biological factors, which have opened new avenues for better therapeutics of cartilage lesions. This review focuses on advances in cartilage tissue engineering, particularly in preclinical trials and clinical applications, prospects, and challenges. {\textcopyright} 2023, Mary Ann Liebert, Inc.",

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author = "Zhen Zhang and Yulei Mu and Huiqun Zhou and Hang Yao and Dong-An Wang",

year = "2023",

month = oct,

day = "12",

doi = "10.1089/ten.teb.2022.0190",

language = "English",

volume = "29",

pages = "473--490",

journal = "Tissue Engineering - Part B: Reviews",

issn = "1937-3368",

publisher = "Mary Ann Liebert, Inc.",

number = "5",

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TY - JOUR

T1 - Cartilage Tissue Engineering in Practice

T2 - Preclinical Trials, Clinical Applications, and Prospects

AU - Zhang, Zhen

AU - Mu, Yulei

AU - Zhou, Huiqun

AU - Yao, Hang

AU - Wang, Dong-An

PY - 2023/10/12

Y1 - 2023/10/12

N2 - Articular cartilage defects significantly compromise the quality of life in the global population. Although many strategies are needed to repair articular cartilage, including microfracture, autologous osteochondral transplantation, and osteochondral allograft, the therapeutic effects remain suboptimal. In recent years, with the development of cartilage tissue engineering, scientists have continuously improved the formulations of therapeutic cells, biomaterial-based scaffolds, and biological factors, which have opened new avenues for better therapeutics of cartilage lesions. This review focuses on advances in cartilage tissue engineering, particularly in preclinical trials and clinical applications, prospects, and challenges. © 2023, Mary Ann Liebert, Inc.

AB - Articular cartilage defects significantly compromise the quality of life in the global population. Although many strategies are needed to repair articular cartilage, including microfracture, autologous osteochondral transplantation, and osteochondral allograft, the therapeutic effects remain suboptimal. In recent years, with the development of cartilage tissue engineering, scientists have continuously improved the formulations of therapeutic cells, biomaterial-based scaffolds, and biological factors, which have opened new avenues for better therapeutics of cartilage lesions. This review focuses on advances in cartilage tissue engineering, particularly in preclinical trials and clinical applications, prospects, and challenges. © 2023, Mary Ann Liebert, Inc.

KW - articular cartilage

KW - tissue engineering

KW - preclinical

KW - clinical

KW - biomaterials

KW - AUTOLOGOUS CHONDROCYTE IMPLANTATION

KW - PLURIPOTENT STEM-CELLS

KW - INTERPENETRATING-NETWORK HYDROGEL

KW - BILAYER COLLAGEN MEMBRANE

KW - MESENCHYMAL STROMAL CELLS

KW - ARTICULAR-CARTILAGE

KW - IN-VITRO

KW - FOLLOW-UP

KW - OSTEOCHONDRAL DEFECTS

KW - EXTRACELLULAR-MATRIX

UR - http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000979374000001

U2 - 10.1089/ten.teb.2022.0190

DO - 10.1089/ten.teb.2022.0190

M3 - RGC 21 - Publication in refereed journal

SN - 1937-3368

VL - 29

SP - 473

EP - 490

JO - Tissue Engineering - Part B: Reviews

JF - Tissue Engineering - Part B: Reviews

IS - 5

ER -

Cartilage Tissue Engineering in Practice: Preclinical Trials, Clinical Applications, and Prospects

Abstract

Funding

Research Keywords

RGC Funding Information

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Fingerprint

GRF: Engineering Osteogenesis with Hypertrophic Chondrocytes in Tissue-engineered Cartilaginous Template for Rudimentary Bone Formation

Type II Collagen as a Versatile Platform for Osteochondral Repair: Strategies for Injectable, Endochondral Ossification, and Drug Release

Cite this

Cartilage Tissue Engineering in Practice: Preclinical Trials, Clinical Applications, and Prospects

Abstract

Funding

Research Keywords

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

GRF: Engineering Osteogenesis with Hypertrophic Chondrocytes in Tissue-engineered Cartilaginous Template for Rudimentary Bone Formation

Student theses

Type II Collagen as a Versatile Platform for Osteochondral Repair: Strategies for Injectable, Endochondral Ossification, and Drug Release

Cite this