Carprofen and buprenorphine prevent hyperalgesia in a model of inflammatory pain in cats

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)369-375
Journal / PublicationResearch in Veterinary Science
Volume83
Issue number3
Publication statusPublished - Dec 2007
Externally publishedYes

Abstract

A model of nociceptive threshold determination was developed for evaluation of NSAID analgesia in cats. In a crossover study, eight cats received carprofen (4 mg/kg), buprenorphine (0.01 mg/kg) or saline (0.3 ml) subcutaneously before intradermal kaolin injection on the antebrachium to induce mild inflammation. Pressure thresholds were measured at the injected site using blunt-ended pins advanced by manual inflation of a bladder within a bracelet. Bladder pressure was recorded as threshold (PT) at the behavioural end point. Baseline PT were recorded before kaolin injection (time 0). PT was measured at 2-10 h intervals for 52 h. PT below the lower 95% confidence interval (CI) of baseline values indicated hyperalgesia. After saline, hyperalgesia was detected from 2-6 h, 22-26 h, and at 30 and 36 h. After carprofen, PT remained within the 95% CI. After buprenorphine, PT remained within the 95% CI except at 2 h. Carprofen and to some extent buprenorphine, prevented inflammatory hyperalgesia. © 2007 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Analgesia, Cat, NSAID, Opioid, Pain, Pressure nociceptive threshold testing

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Citation Format(s)

Carprofen and buprenorphine prevent hyperalgesia in a model of inflammatory pain in cats. / Taylor, P. M.; Steagall, P. V.M.; Dixon, M. J.; Ferreira, T. H.; Luna, S. P.L.

In: Research in Veterinary Science, Vol. 83, No. 3, 12.2007, p. 369-375.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review