Candidate gene polymorphisms (BoIFNG, TLR4, SLC11A1) as risk factors for paratuberculosis infection in cattle

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Pablo J. Pinedo
  • Claus D. Buergelt
  • G. Art Donovan
  • Laurence Morel
  • Rongling Wu
  • Taimour Y. Langaee
  • D. Owen Rae

Detail(s)

Original languageEnglish
Pages (from-to)189-196
Journal / PublicationPreventive Veterinary Medicine
Volume91
Issue number2-4
Publication statusPublished - 1 Oct 2009
Externally publishedYes

Abstract

Paratuberculosis (Johne's disease) imposes a significant problem to the world dairy and beef industries and today is considered a potential zoonosis. The disease is caused by Mycobacterium avium subsp. paratuberculosis and is characterized by progressive weight loss and profuse diarrhoea. Susceptibility to infection is suspected to have a genetic component, and moderated values for heritability of infection have been reported. Interferon gamma is an inducible cytokine with a crucial role in the innate host response to intracellular bacteria. Toll-like receptors are trans-membrane structures responsible for coordination of innate and adaptive immune responses. The solute carrier family 11 member 1 (SLC11A1, formerly NRAMP1) gene plays an important role in innate immunity, preventing bacterial growth in macrophages during the initial stages of infection. The objective of this candidate gene case-control study was to characterize the distribution of polymorphisms in three candidate genes related to the immune function; interferon gamma (BoIFNG), toll-like receptor 4 (TLR4), and SLC11A1 genes and to test their role as potential risk factors for paratuberculosis infection in cattle. The statistical analysis demonstrated significant differences in allelic frequencies between cases and controls for BoIFNG-SNP12781 and SLC11A1 microsatellites, indicating a significant association between infection and variant alleles. In the analysis of genotypes, a significant association was also found between infection status and BoIFNG-SNP12781 and SLC11A1-275-279-281 microsatellites. However, when variables such as breed and age were included in the multivariate logistic regression analysis, a tendency toward statistical significance for the effect of polymorphisms in the odds of infection was only found for alleles SLC11A1-275 and 279. © 2009 Elsevier B.V. All rights reserved.

Research Area(s)

  • Genetic, Paratuberculosis, Risk, Susceptibility

Bibliographic Note

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Citation Format(s)

Candidate gene polymorphisms (BoIFNG, TLR4, SLC11A1) as risk factors for paratuberculosis infection in cattle. / Pinedo, Pablo J.; Buergelt, Claus D.; Donovan, G. Art et al.
In: Preventive Veterinary Medicine, Vol. 91, No. 2-4, 01.10.2009, p. 189-196.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review