CANCER CELL-SPECIFIC OLIGOPEPTIDE SELECTED BY MICROFLUIDIC SYSTEM FROM A PHAGE DISPLAY LIBRARY FOR OVARIAN CANCER DIAGNOSIS

C.H. Wang; C.-H. Weng; Y.-J. Che; K. Wang; G.-B. Lee

CANCER CELL-SPECIFIC OLIGOPEPTIDE SELECTED BY MICROFLUIDIC SYSTEM FROM A PHAGE DISPLAY LIBRARY FOR OVARIAN CANCER DIAGNOSIS

C.H. Wang
, C.-H. Weng
, Y.-J. Che
, K. Wang
, G.-B. Lee

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

Ovarian cancer has been one of the leading causes of death for women. However, it is still very challenging for its early diagnosis. The tedious conventional methods for screening specific biomarkers need at least two weeks or more. It was reported that cancer-specific oligopeptides could be screened from a phage display library. In this study, a new integrated microfluidic chip was developed to perform the entire screening process for specific oligopeptide selection of ovarian cancer cells. The screened oligopeptide was demonstrated to have high affinity with ovarian cancer cells and relatively low capture rate with other types of cancer cells. It is therefore promising to use the screened oligopeptide for isolation of ovarian cancer cells in the near future.

Original language	English
Title of host publication	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013)
Publisher	Chemical and Biological Microsystems Society
Pages	1953-1955
ISBN (Print)	9781632666246
Publication status	Published - Oct 2013
Externally published	Yes
Event	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013) - Messe Freiburg, Freiburg, Germany Duration: 27 Oct 2013 → 31 Oct 2013

Publication series

Name	International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS

Conference

Conference	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013)
Place	Germany
City	Freiburg
Period	27/10/13 → 31/10/13

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Biomarker
Microfluidic
Ovarian cancer
Phage display library

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Wang, C. H., Weng, C.-H., Che, Y.-J., Wang, K., & Lee, G.-B. (2013). CANCER CELL-SPECIFIC OLIGOPEPTIDE SELECTED BY MICROFLUIDIC SYSTEM FROM A PHAGE DISPLAY LIBRARY FOR OVARIAN CANCER DIAGNOSIS. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013) (pp. 1953-1955). (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS). Chemical and Biological Microsystems Society.

Wang, C.H. ; Weng, C.-H. ; Che, Y.-J. et al. / CANCER CELL-SPECIFIC OLIGOPEPTIDE SELECTED BY MICROFLUIDIC SYSTEM FROM A PHAGE DISPLAY LIBRARY FOR OVARIAN CANCER DIAGNOSIS. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013). Chemical and Biological Microsystems Society, 2013. pp. 1953-1955 (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

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title = "CANCER CELL-SPECIFIC OLIGOPEPTIDE SELECTED BY MICROFLUIDIC SYSTEM FROM A PHAGE DISPLAY LIBRARY FOR OVARIAN CANCER DIAGNOSIS",

abstract = "Ovarian cancer has been one of the leading causes of death for women. However, it is still very challenging for its early diagnosis. The tedious conventional methods for screening specific biomarkers need at least two weeks or more. It was reported that cancer-specific oligopeptides could be screened from a phage display library. In this study, a new integrated microfluidic chip was developed to perform the entire screening process for specific oligopeptide selection of ovarian cancer cells. The screened oligopeptide was demonstrated to have high affinity with ovarian cancer cells and relatively low capture rate with other types of cancer cells. It is therefore promising to use the screened oligopeptide for isolation of ovarian cancer cells in the near future.",

keywords = "Biomarker, Microfluidic, Ovarian cancer, Phage display library",

author = "C.H. Wang and C.-H. Weng and Y.-J. Che and K. Wang and G.-B. Lee",

year = "2013",

month = oct,

language = "English",

isbn = "9781632666246",

series = "International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS",

publisher = "Chemical and Biological Microsystems Society",

pages = "1953--1955",

booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013)",

note = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013) ; Conference date: 27-10-2013 Through 31-10-2013",

}

Wang, CH, Weng, C-H, Che, Y-J, Wang, K & Lee, G-B 2013, CANCER CELL-SPECIFIC OLIGOPEPTIDE SELECTED BY MICROFLUIDIC SYSTEM FROM A PHAGE DISPLAY LIBRARY FOR OVARIAN CANCER DIAGNOSIS. in 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013). International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS, Chemical and Biological Microsystems Society, pp. 1953-1955, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013), Freiburg, Germany, 27/10/13.

CANCER CELL-SPECIFIC OLIGOPEPTIDE SELECTED BY MICROFLUIDIC SYSTEM FROM A PHAGE DISPLAY LIBRARY FOR OVARIAN CANCER DIAGNOSIS. / Wang, C.H.; Weng, C.-H.; Che, Y.-J. et al.
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013). Chemical and Biological Microsystems Society, 2013. p. 1953-1955 (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - CANCER CELL-SPECIFIC OLIGOPEPTIDE SELECTED BY MICROFLUIDIC SYSTEM FROM A PHAGE DISPLAY LIBRARY FOR OVARIAN CANCER DIAGNOSIS

AU - Wang, C.H.

AU - Weng, C.-H.

AU - Che, Y.-J.

AU - Wang, K.

AU - Lee, G.-B.

PY - 2013/10

Y1 - 2013/10

N2 - Ovarian cancer has been one of the leading causes of death for women. However, it is still very challenging for its early diagnosis. The tedious conventional methods for screening specific biomarkers need at least two weeks or more. It was reported that cancer-specific oligopeptides could be screened from a phage display library. In this study, a new integrated microfluidic chip was developed to perform the entire screening process for specific oligopeptide selection of ovarian cancer cells. The screened oligopeptide was demonstrated to have high affinity with ovarian cancer cells and relatively low capture rate with other types of cancer cells. It is therefore promising to use the screened oligopeptide for isolation of ovarian cancer cells in the near future.

AB - Ovarian cancer has been one of the leading causes of death for women. However, it is still very challenging for its early diagnosis. The tedious conventional methods for screening specific biomarkers need at least two weeks or more. It was reported that cancer-specific oligopeptides could be screened from a phage display library. In this study, a new integrated microfluidic chip was developed to perform the entire screening process for specific oligopeptide selection of ovarian cancer cells. The screened oligopeptide was demonstrated to have high affinity with ovarian cancer cells and relatively low capture rate with other types of cancer cells. It is therefore promising to use the screened oligopeptide for isolation of ovarian cancer cells in the near future.

KW - Biomarker

KW - Microfluidic

KW - Ovarian cancer

KW - Phage display library

UR - https://www.scopus.com/pages/publications/84907347728

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84907347728&origin=recordpage

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781632666246

T3 - International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS

SP - 1953

EP - 1955

BT - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013)

PB - Chemical and Biological Microsystems Society

T2 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013)

Y2 - 27 October 2013 through 31 October 2013

ER -

Wang CH, Weng CH, Che YJ, Wang K, Lee GB. CANCER CELL-SPECIFIC OLIGOPEPTIDE SELECTED BY MICROFLUIDIC SYSTEM FROM A PHAGE DISPLAY LIBRARY FOR OVARIAN CANCER DIAGNOSIS. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013). Chemical and Biological Microsystems Society. 2013. p. 1953-1955. (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

CANCER CELL-SPECIFIC OLIGOPEPTIDE SELECTED BY MICROFLUIDIC SYSTEM FROM A PHAGE DISPLAY LIBRARY FOR OVARIAN CANCER DIAGNOSIS

Abstract

Publication series

Conference

UN SDGs

Research Keywords

Other Access Options

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