Abstract
The application of nanodiamond is rapidly expanded from diagnosis to treatment due to its promising drug loading and non-photo-quenching imaging properties. However, the delivery of sufficient drug amount to the targeted disease site is greatly important in therapeutics. Hence, we developed a cancer-cell-specific sub-cellular organelle-targeted delivery based on photostable Nanodiamond (ND), which is functionalized with folic acid and Mitochondrial Localizing Sequence (MLS) peptides. This dual-ligand-functionalized ND platform does not only distinguish the cancer cells via the overexpression of folate receptors on cell membrane, it also localizes to mitochondria. Importantly, the Doxorubicin (DOX) loaded dual-ligandfunctionalized ND platform induces a significant cytotoxicity in drug resistance cancer cell (MCF-7/ADR) comparing to the free Doxorubicin localized in lysosomes because the localization in mitochondria enhances the retention time of DOX inside the MCF-7/ADR, which has the significant circumvention of P-glycoprotein to pump out the drug inside the cell. This work successfully demonstrates nanodiamond-based nanocarriers for cancer-cell- specific mitochondria-targeted delivery and overcomes drug resistance in Doxorubicin-resistant human breast adenocarcinoma cancer cells.
| Original language | English |
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| Publication status | Published - May 2018 |
| Event | 2nd International Conference and Exhibition on Nanomedicine and Drug Delivery - Tokyo, Japan Duration: 21 May 2018 → 23 May 2018 https://nanomedicine.pharmaceuticalconferences.com/scientific-program https://www.scitechnol.com/conference-abstracts/nanodelivery-2018-proceedings.html |
Conference
| Conference | 2nd International Conference and Exhibition on Nanomedicine and Drug Delivery |
|---|---|
| Place | Japan |
| City | Tokyo |
| Period | 21/05/18 → 23/05/18 |
| Internet address |
