Can the triumph of mRNA vaccines against COVID-19 be extended to other viral infections of humans and domesticated animals?

Sharvan Sehrawat; Nikolaus Osterrieder; D. Scott Schmid; Barry T. Rouse

doi:10.1016/j.micinf.2022.105078

Can the triumph of mRNA vaccines against COVID-19 be extended to other viral infections of humans and domesticated animals?

Sharvan Sehrawat^*, Nikolaus Osterrieder, D. Scott Schmid, Barry T. Rouse^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

1 Citation (Scopus)

Abstract

The unprecedented success of mRNA vaccines in managing the COVID-19 pandemic raises the prospect of applying the mRNA platform to other viral diseases of humans and domesticated animals, which may lead to more efficacious vaccines for some agents. We briefly discuss reasons why mRNA vaccines achieved such success against COVID-19 and indicate what other virus infections and disease conditions might also be ripe for control using mRNA vaccines. We also evaluate situations where mRNA could prove valuable to rebalance the status of immune responsiveness and achieve success as a therapeutic vaccine approach against infections that induce immunoinflammatory lesions.

Original language	English
Article number	105078
Journal	Microbes and Infection
Volume	25
Issue number	1-2
Online published	23 Nov 2022
DOIs	https://doi.org/10.1016/j.micinf.2022.105078
Publication status	Published - Jan 2023

Research Keywords

COVID-19
Human and animals
Immunopathology
mRNA vaccines
Virus infections

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@article{f3ced8a4383c465196449127beacaa7e,

title = "Can the triumph of mRNA vaccines against COVID-19 be extended to other viral infections of humans and domesticated animals?",

abstract = "The unprecedented success of mRNA vaccines in managing the COVID-19 pandemic raises the prospect of applying the mRNA platform to other viral diseases of humans and domesticated animals, which may lead to more efficacious vaccines for some agents. We briefly discuss reasons why mRNA vaccines achieved such success against COVID-19 and indicate what other virus infections and disease conditions might also be ripe for control using mRNA vaccines. We also evaluate situations where mRNA could prove valuable to rebalance the status of immune responsiveness and achieve success as a therapeutic vaccine approach against infections that induce immunoinflammatory lesions.",

keywords = "COVID-19, Human and animals, Immunopathology, mRNA vaccines, Virus infections",

author = "Sharvan Sehrawat and Nikolaus Osterrieder and Schmid, {D. Scott} and Rouse, {Barry T.}",

year = "2023",

month = jan,

doi = "10.1016/j.micinf.2022.105078",

language = "English",

volume = "25",

journal = "Microbes and Infection",

issn = "1286-4579",