Calibration-free structured-illumination photoacoustic flowgraphy of transverse flow in scattering media

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

10 Scopus Citations
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Author(s)

  • Junjie Yao
  • Rebecca C. Gilson
  • Konstantin I. Maslov
  • Lidai Wang
  • Lihong V. Wang

Detail(s)

Original languageEnglish
Article number46007
Journal / PublicationJournal of Biomedical Optics
Volume19
Issue number4
Publication statusPublished - Apr 2014
Externally publishedYes

Abstract

We propose a calibration-free photoacoustic (PA) method for transverse flow measurements. In this method, a pulsed periodically structured (i.e., grating patterned) optical beam is used to illuminate flowing absorptive particles in an optically scattering medium. The PA signal amplitudes measured over consecutive laser pulses carry an imprint of the illumination structure. The modulation frequency of the imprint is proportional to the component of the flow speed projected onto the normal axis of the striped illumination pattern. This method can tolerate high particle density, and is insensitive to the particle size, thus calibration-free. Bovine blood and microsphere phantoms were used to validate the proposed method. Blood flow in a mouse ear was measured in vivo as well. © Society of Photo-Optical Instrumentation Engineers.

Research Area(s)

  • frequency shift, particle size independent, photoacoustic flowgraphy, structured illumination

Citation Format(s)

Calibration-free structured-illumination photoacoustic flowgraphy of transverse flow in scattering media. / Yao, Junjie; Gilson, Rebecca C.; Maslov, Konstantin I. et al.
In: Journal of Biomedical Optics, Vol. 19, No. 4, 46007, 04.2014.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review