Calibration-free quantification of absolute oxygen saturation based on the dynamics of photoacoustic signals

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jun Xia
  • Amos Danielli
  • Yan Liu
  • Konstantin Maslov
  • Lihong V. Wang

Detail(s)

Original languageEnglish
Pages (from-to)2800-2803
Journal / PublicationOptics Letters
Volume38
Issue number15
Publication statusPublished - 1 Aug 2013
Externally publishedYes

Abstract

Photoacoustic tomography (PAT) is a hybrid imaging technique that has broad preclinical and clinical applications. Based on the photoacoustic effect, PAT directly measures specific optical absorption, which is the product of the tissue-intrinsic optical absorption coefficient and the local optical fluence. Therefore, quantitative PAT, such as absolute oxygen saturation (sO2) quantification, requires knowledge of the local optical fluence, which can only be estimated through invasive measurements or sophisticated modeling of light transportation. In this Letter, we circumvent this requirement by taking advantage of the dynamics in sO2. The new method works when the sO2 transition can be simultaneously monitored with multiple wavelengths. For each wavelength, the ratio of photoacoustic amplitudes measured at different sO2 states is utilized. Using the ratio cancels the contribution from optical fluence and allows calibration-free quantification of absolute sO2. The new method was validated through both phantom and in vivo experiments. © 2013 Optical Society of America.

Citation Format(s)

Calibration-free quantification of absolute oxygen saturation based on the dynamics of photoacoustic signals. / Xia, Jun; Danielli, Amos; Liu, Yan et al.
In: Optics Letters, Vol. 38, No. 15, 01.08.2013, p. 2800-2803.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review