TY - JOUR
T1 - Calf-level factors associated with bovine neonatal pancytopenia - A multi-country case-control study
AU - Jones, Bryony A.
AU - Sauter-Louis, Carola
AU - Henning, Joerg
AU - Stoll, Alexander
AU - Nielen, Mirjam
AU - Van Schaik, Gerdien
AU - Smolenaars, Anja
AU - Schouten, Matthijs
AU - Den Uijl, Ingrid
AU - Fourichon, Christine
AU - Guatteo, Raphael
AU - Madouasse, Aurélien
AU - Nusinovici, Simon
AU - Deprez, Piet
AU - De Vliegher, Sarne
AU - Laureyns, Jozef
AU - Booth, Richard
AU - Cardwell, Jackie M.
AU - Pfeiffer, Dirk U.
PY - 2013/12/2
Y1 - 2013/12/2
N2 - Bovine neonatal pancytopenia (BNP), a high fatality condition causing haemorrhages in calves aged less than 4 weeks, was first reported in 2007 in Germany and subsequently observed at low incidence in other European countries and New Zealand. A multi-country matched case-control study was conducted in 2011 to identify calf-level risk factors for BNP. 405 BNP cases were recruited from 330 farms in Belgium, France, Germany and the Netherlands by laboratory confirmation of farmer-reported cases. Up to four calves of similar age from the same farm were selected as controls (1154 calves). Risk factor data were collected by questionnaire. Multivariable modelling using conditional logistic regression indicated that Preg Sure HBVD (Preg Sure, Pfizer Animal Health) vaccination of the dam was strongly associated with BNP cases (adjusted matched Odds Ratio - am OR 17.8 first lactation dams; 95% confidence interval - ci 2.4, 134.4; p = 0.005), and second or more lactation Preg Sure-vaccinated dams were more likely to have a case than first lactation vaccinated dams (am OR 2.2 second lactation; ci 1.1, 4.3; p = 0.024; am OR 5.3 third or more lactation; ci 2.9, 9.8; p =
AB - Bovine neonatal pancytopenia (BNP), a high fatality condition causing haemorrhages in calves aged less than 4 weeks, was first reported in 2007 in Germany and subsequently observed at low incidence in other European countries and New Zealand. A multi-country matched case-control study was conducted in 2011 to identify calf-level risk factors for BNP. 405 BNP cases were recruited from 330 farms in Belgium, France, Germany and the Netherlands by laboratory confirmation of farmer-reported cases. Up to four calves of similar age from the same farm were selected as controls (1154 calves). Risk factor data were collected by questionnaire. Multivariable modelling using conditional logistic regression indicated that Preg Sure HBVD (Preg Sure, Pfizer Animal Health) vaccination of the dam was strongly associated with BNP cases (adjusted matched Odds Ratio - am OR 17.8 first lactation dams; 95% confidence interval - ci 2.4, 134.4; p = 0.005), and second or more lactation Preg Sure-vaccinated dams were more likely to have a case than first lactation vaccinated dams (am OR 2.2 second lactation; ci 1.1, 4.3; p = 0.024; am OR 5.3 third or more lactation; ci 2.9, 9.8; p =
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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84891398132&origin=recordpage
U2 - 10.1371/journal.pone.0080619
DO - 10.1371/journal.pone.0080619
M3 - RGC 21 - Publication in refereed journal
C2 - 24312485
SN - 1932-6203
VL - 8
JO - PLoS ONE
JF - PLoS ONE
IS - 12
M1 - e80619
ER -