Abstract
Objective: To examine the association between serum c-reactive protein (CRP) concentration and the metabolic syndrome (MS) using the International Diabetes Federation Metabolic Syndrome Guidelines (April, 2005) definition in an older Chinese population.
Methods: Three thousand and fourteen men and 7275 women aged 50-85 years were recruited and received a full medical check-up including measurement of blood pressure, obesity indices, fasting total, LDL-, HDL-cholesterol, triglycerides, glucose and c-reactive protein. Data describing socioeconomic and lifestyle factors was also collected.
Results: Vascular risk factors including waist circumference, weight gain and waist gain since the age of 18, body mass index, waist-hip-ratio, triglyceride, HDL-cholesterol, and systolic and diastolic blood pressures were positively associated with CRP in both men and women (p from <0.001 to 0.016). Compared to those without MS components, adjusted odds ratios for having elevated CRP increased in those with the MS or its components compared those without MS or components (all p < 0.001), except for the low HDL-cholesterol in both genders and raised fasting glucose in men. Similarly, the risk of elevated CRP increased with escalating MS components even after adjustment of a range of potential confounders.
Conclusions: There is a strong relationship between CRP and the constellation of MS components and associated vascular risk in this older Chinese population.
© 2006 Elsevier Ireland Ltd. All rights reserved.
Methods: Three thousand and fourteen men and 7275 women aged 50-85 years were recruited and received a full medical check-up including measurement of blood pressure, obesity indices, fasting total, LDL-, HDL-cholesterol, triglycerides, glucose and c-reactive protein. Data describing socioeconomic and lifestyle factors was also collected.
Results: Vascular risk factors including waist circumference, weight gain and waist gain since the age of 18, body mass index, waist-hip-ratio, triglyceride, HDL-cholesterol, and systolic and diastolic blood pressures were positively associated with CRP in both men and women (p from <0.001 to 0.016). Compared to those without MS components, adjusted odds ratios for having elevated CRP increased in those with the MS or its components compared those without MS or components (all p < 0.001), except for the low HDL-cholesterol in both genders and raised fasting glucose in men. Similarly, the risk of elevated CRP increased with escalating MS components even after adjustment of a range of potential confounders.
Conclusions: There is a strong relationship between CRP and the constellation of MS components and associated vascular risk in this older Chinese population.
© 2006 Elsevier Ireland Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 483-489 |
| Number of pages | 7 |
| Journal | Atherosclerosis |
| Volume | 194 |
| Issue number | 2 |
| Online published | 28 Sept 2006 |
| DOIs | |
| Publication status | Published - Oct 2007 |
| Externally published | Yes |
Funding
The study was funded by The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. We would also like to thank Prof. Sir Richard Peto and Dr. Z.M. Chen of the Clinical Trial Service Unit, The University of Oxford for their support. The Guangzhou Biobank Cohort Study investigators include: Guangzhou No. 12 Hospital: X.Q. Lao, W.S. Zhang, M. Cao, T. Zhu, B. Liu, C.Q. Jiang (Co-PI); The University of Hong Kong: G.N. Thomas, M. Schooling, S.M. McGhee, G.M. Leung, R.F. Fielding, T.H. Lam (Co-PI); The University of Birmingham: P. Adab, K.K. Cheng (Co-PI).
Research Keywords
- c-Reactive protein
- Chinese
- Metabolic syndrome
- Vascular risk factors
