Bright, Magnetic NIR-II Quantum Dot Probe for Sensitive Dual-Modality Imaging and Intensive Combination Therapy of Cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

4 Scopus Citations
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Author(s)

  • Yingying Li
  • Peisen Zhang
  • Wen Tang
  • Kevin J. Mchugh
  • Stephen V. Kershaw
  • And 10 others
  • Mingxia Jiao
  • Xiaodan Huang
  • Sergii Kalytchuk
  • Collin F. Perkinson
  • Saisai Yue
  • Yuanyuan Qiao
  • Lichong Zhu
  • Lihong Jing
  • Mingyuan Gao
  • Buxing Han

Detail(s)

Original languageEnglish
Pages (from-to)8076–8094
Journal / PublicationACS Nano
Volume16
Issue number5
Online published20 Apr 2022
Publication statusPublished - 24 Apr 2022

Abstract

Improving the effectiveness of cancer therapy will require tools that enable more specific cancer targeting and improved tumor visualization. Theranostics have the potential for improving cancer care because of their ability to serve as both diagnostics and therapeutics; however, their diagnostic potential is often limited by tissue-associated light absorption and scattering. Herein, we develop CuInSe2@ZnS:Mn quantum dots (QDs) with intrinsic multifunctionality that both enable the accurate localization of small metastases and act as potent tumor ablation agents. By leveraging the growth kinetics of a ZnS shell on a biocompatible CuInSe2 core, Mn doping, and folic acid functionalization, we produce biocompatible QDs with high near-infrared (NIR)-II fluorescence efficiency up to 31.2%, high contrast on magnetic resonance imaging (MRI), and preferential distribution in 4T1 breast cancer tumors. MRI-enabled contrast of these nanoprobes is sufficient to timely identify small metastases in the lungs, which is critically important for preventing cancer spreading and recurrence. Further, exciting tumor-resident QDs with NIR light produces both fluorescence for tumor visualization through radiative recombination pathways as well as heat and radicals through nonradiative recombination pathways that kill cancer cells and initiate an anticancer immune response, which eliminates tumor and prevents tumor regrowth in 80% of mice.

Research Area(s)

  • cancer theranostics, exciton recombination pathways, intrinsic multifunctionality, NIR-II emission, semiconductor quantum dots

Citation Format(s)

Bright, Magnetic NIR-II Quantum Dot Probe for Sensitive Dual-Modality Imaging and Intensive Combination Therapy of Cancer. / Li, Yingying; Zhang, Peisen; Tang, Wen; Mchugh, Kevin J.; Kershaw, Stephen V.; Jiao, Mingxia; Huang, Xiaodan; Kalytchuk, Sergii; Perkinson, Collin F.; Yue, Saisai; Qiao, Yuanyuan; Zhu, Lichong; Jing, Lihong; Gao, Mingyuan; Han, Buxing.

In: ACS Nano, Vol. 16, No. 5, 24.04.2022, p. 8076–8094.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review