Bone integration capability of a series of strontium-containing hydroxyapatite coatings formed by micro-arc oxidation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)2465-2480
Journal / PublicationJournal of Biomedical Materials Research - Part A
Volume101 A
Issue number9
Publication statusPublished - Sep 2013

Abstract

Strontium-containing hydroxyapatites (Sr-HA) combine the desirable bone regenerative properties of hydroxyapatites (HA) with anabolic and anti-catabolic effects of strontium cations. In the present work, a series of SryHA [SryCa(10-y)(PO4)6(OH)2; y = 0, 0.5, 1, 2] coatings on titanium are produced by micro-arc oxidation (MAO), and the effects of the in vivo osseointegration ability of the coatings are investigated by using a rabbit model. All samples are subjected to biomechanical, surface elemental, micro-CT and histological analysis after 4 and 12 weeks of healing. The obtained results show that the MAO-formed coatings exhibit a microporous network structure composed of SryHA/Sr yHA-SrxCa(1-x)TiO3/Sr xCa(1-x)TiO3-TiO2 multilayers, in which the outer SryHA and intermediate SryHA-Sr xCa(1-x)TiO3 layers have a nanocrystalline structure. All Sr-HA coated implants induce marked improvements in the behavior of bone formation, quantity and quality of bone tissue around the implants than the control HA implant and in particular, the 20%Sr-HA coating promotes early bone formation as identified by polyfluorochrome sequential labeling. The bone-to-implant contact is increased by 46% (p <0.05) and the pull-out strength is increased by 103% over the HA group (p <0.01). Extensive areas of mineralized tissue densely deposit on the 20%Sr-HA coating after biomechanical testing, and the greatest improvement of bone microarchitecture are observed around the 20%Sr-HA implant. The identified biological parameters successfully demonstrate the osteoconductivity of 20%Sr-HA surfaces, which results not only in an acceleration but also an improvement of bone-implant integration. The study demonstrates the immense potential of 20%Sr-HA coatings in dental and orthopedic applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 2465-2480, 2013. Copyright © 2012 Wiley Periodicals, Inc.

Research Area(s)

  • coating, in vivo implantation, micro-arc oxidation, osseointegration, Sr-doped hydroxyapatite, titanium

Citation Format(s)

Bone integration capability of a series of strontium-containing hydroxyapatite coatings formed by micro-arc oxidation. / Yan, Jun; Sun, Ji-Feng; Chu, Paul K.; Han, Yong; Zhang, Yu-Mei.

In: Journal of Biomedical Materials Research - Part A, Vol. 101 A, No. 9, 09.2013, p. 2465-2480.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review