TY - JOUR
T1 - Bone integration capability of a series of strontium-containing hydroxyapatite coatings formed by micro-arc oxidation
AU - Yan, Jun
AU - Sun, Ji-Feng
AU - Chu, Paul K.
AU - Han, Yong
AU - Zhang, Yu-Mei
PY - 2013/9
Y1 - 2013/9
N2 - Strontium-containing hydroxyapatites (Sr-HA) combine the desirable bone regenerative properties of hydroxyapatites (HA) with anabolic and anti-catabolic effects of strontium cations. In the present work, a series of SryHA [SryCa(10-y)(PO4)6(OH)2; y = 0, 0.5, 1, 2] coatings on titanium are produced by micro-arc oxidation (MAO), and the effects of the in vivo osseointegration ability of the coatings are investigated by using a rabbit model. All samples are subjected to biomechanical, surface elemental, micro-CT and histological analysis after 4 and 12 weeks of healing. The obtained results show that the MAO-formed coatings exhibit a microporous network structure composed of SryHA/Sr yHA-SrxCa(1-x)TiO3/Sr xCa(1-x)TiO3-TiO2 multilayers, in which the outer SryHA and intermediate SryHA-Sr xCa(1-x)TiO3 layers have a nanocrystalline structure. All Sr-HA coated implants induce marked improvements in the behavior of bone formation, quantity and quality of bone tissue around the implants than the control HA implant and in particular, the 20%Sr-HA coating promotes early bone formation as identified by polyfluorochrome sequential labeling. The bone-to-implant contact is increased by 46% (p <0.05) and the pull-out strength is increased by 103% over the HA group (p <0.01). Extensive areas of mineralized tissue densely deposit on the 20%Sr-HA coating after biomechanical testing, and the greatest improvement of bone microarchitecture are observed around the 20%Sr-HA implant. The identified biological parameters successfully demonstrate the osteoconductivity of 20%Sr-HA surfaces, which results not only in an acceleration but also an improvement of bone-implant integration. The study demonstrates the immense potential of 20%Sr-HA coatings in dental and orthopedic applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 2465-2480, 2013. Copyright © 2012 Wiley Periodicals, Inc.
AB - Strontium-containing hydroxyapatites (Sr-HA) combine the desirable bone regenerative properties of hydroxyapatites (HA) with anabolic and anti-catabolic effects of strontium cations. In the present work, a series of SryHA [SryCa(10-y)(PO4)6(OH)2; y = 0, 0.5, 1, 2] coatings on titanium are produced by micro-arc oxidation (MAO), and the effects of the in vivo osseointegration ability of the coatings are investigated by using a rabbit model. All samples are subjected to biomechanical, surface elemental, micro-CT and histological analysis after 4 and 12 weeks of healing. The obtained results show that the MAO-formed coatings exhibit a microporous network structure composed of SryHA/Sr yHA-SrxCa(1-x)TiO3/Sr xCa(1-x)TiO3-TiO2 multilayers, in which the outer SryHA and intermediate SryHA-Sr xCa(1-x)TiO3 layers have a nanocrystalline structure. All Sr-HA coated implants induce marked improvements in the behavior of bone formation, quantity and quality of bone tissue around the implants than the control HA implant and in particular, the 20%Sr-HA coating promotes early bone formation as identified by polyfluorochrome sequential labeling. The bone-to-implant contact is increased by 46% (p <0.05) and the pull-out strength is increased by 103% over the HA group (p <0.01). Extensive areas of mineralized tissue densely deposit on the 20%Sr-HA coating after biomechanical testing, and the greatest improvement of bone microarchitecture are observed around the 20%Sr-HA implant. The identified biological parameters successfully demonstrate the osteoconductivity of 20%Sr-HA surfaces, which results not only in an acceleration but also an improvement of bone-implant integration. The study demonstrates the immense potential of 20%Sr-HA coatings in dental and orthopedic applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 2465-2480, 2013. Copyright © 2012 Wiley Periodicals, Inc.
KW - coating
KW - in vivo implantation
KW - micro-arc oxidation
KW - osseointegration
KW - Sr-doped hydroxyapatite
KW - titanium
UR - http://www.scopus.com/inward/record.url?scp=84880599516&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84880599516&origin=recordpage
U2 - 10.1002/jbm.a.34548
DO - 10.1002/jbm.a.34548
M3 - RGC 21 - Publication in refereed journal
C2 - 23348908
SN - 0021-9304
VL - 101 A
SP - 2465
EP - 2480
JO - Journal of Biomedical Materials Research - Part A
JF - Journal of Biomedical Materials Research - Part A
IS - 9
ER -