Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

Chen Xie; Ho-Fai Chau; Jing-Xiang Zhang; Sheng Tong; Lijun Jiang; Wan-Yiu Fok; Hong-Lok Lung; Shuai Zha; Rui Zou; Ju Jiao; Chi-Fai Ng; Ping'an Ma; Junhui Zhang; Jun Lin; Kwok Keung Shiu; Jean-Claude G. Bünzli; Wai-Kwok Wong; Nicholas J. Long; Ga-Lai Law; Ka-Leung Wong

doi:10.1002/adtp.201900068

Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

Chen Xie (Co-first Author), Ho-Fai Chau (Co-first Author), Jing-Xiang Zhang, Sheng Tong, Lijun Jiang, Wan-Yiu Fok, Hong-Lok Lung, Shuai Zha, Rui Zou, Ju Jiao, Chi-Fai Ng, Ping'an Ma, Junhui Zhang, Jun Lin, Kwok Keung Shiu, Jean-Claude G. Bünzli, Wai-Kwok Wong, Nicholas J. Long^*, Ga-Lai Law^*, Ka-Leung Wong^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

24 Citations (Scopus)

Abstract

Acting as an extracellular matrix protein receptor, α_Vβ₃ integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific α_Vβ₃-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-Rⁿ) are demonstrated as off-on theranostic agents, where Rⁿ are specific peptides. Among them, Gd-PEG-R³ shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity of Gd-PEG-R³ is proven by its high α_Vβ₃ integrin binding affinity in positive bladder cancer cells. All these findings support Gd-PEG-R³ as a promising bi-functional medical agent with both MRI contrasting ability and photodynamic therapeutic potential for curing bladder cancer. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Article number	1900068
Number of pages	7
Journal	Advanced Therapeutics
Volume	2
Issue number	11
Online published	16 Aug 2019
DOIs	https://doi.org/10.1002/adtp.201900068
Publication status	Published - Nov 2019
Externally published	Yes

Funding

This work was supported by grants from The Hong Kong Research Grant Council (HKBU12309516), the Hong Kong Baptist University (RC-ICRS/16-17/02-CHEM), CAS Croucher joint lab (CA18204), The Hong Kong Polytechnic University [Univeristy Research Facility for Chemical and Environmental Analysis (UCEA)]and The University Research Facility in Life Sciences (ULS), and The Hong Kong Research Grant Council PolyU 153013/17P and PolyU 153103/16P, also by the assistance from the Imperial College London.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

bladder cancer
lanthanide
magnetic resonance imaging
photodynamic therapy
porphyrin

RGC Funding Information

RGC-funded

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10.1002/adtp.201900068

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Xie, C., Chau, H.-F., Zhang, J.-X., Tong, S., Jiang, L., Fok, W.-Y., Lung, H.-L., Zha, S., Zou, R., Jiao, J., Ng, C.-F., Ma, P., Zhang, J., Lin, J., Shiu, K. K., Bünzli, J.-C. G., Wong, W.-K., Long, N. J., Law, G.-L., & Wong, K.-L. (2019). Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement. Advanced Therapeutics, 2(11), Article 1900068. https://doi.org/10.1002/adtp.201900068

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title = "Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement",

abstract = "Acting as an extracellular matrix protein receptor, αVβ3 integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific αVβ3-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-Rn) are demonstrated as off-on theranostic agents, where Rn are specific peptides. Among them, Gd-PEG-R3 shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity of Gd-PEG-R3 is proven by its high αVβ3 integrin binding affinity in positive bladder cancer cells. All these findings support Gd-PEG-R3 as a promising bi-functional medical agent with both MRI contrasting ability and photodynamic therapeutic potential for curing bladder cancer. {\textcopyright} 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

keywords = "bladder cancer, lanthanide, magnetic resonance imaging, photodynamic therapy, porphyrin",

author = "Chen Xie and Ho-Fai Chau and Jing-Xiang Zhang and Sheng Tong and Lijun Jiang and Wan-Yiu Fok and Hong-Lok Lung and Shuai Zha and Rui Zou and Ju Jiao and Chi-Fai Ng and Ping'an Ma and Junhui Zhang and Jun Lin and Shiu, {Kwok Keung} and B{\"u}nzli, {Jean-Claude G.} and Wai-Kwok Wong and Long, {Nicholas J.} and Ga-Lai Law and Ka-Leung Wong",

year = "2019",

month = nov,

doi = "10.1002/adtp.201900068",

language = "English",

volume = "2",

number = "11",

}

Xie, C, Chau, H-F, Zhang, J-X, Tong, S, Jiang, L, Fok, W-Y, Lung, H-L, Zha, S, Zou, R, Jiao, J, Ng, C-F, Ma, P, Zhang, J, Lin, J, Shiu, KK, Bünzli, J-CG, Wong, W-K, Long, NJ, Law, G-L & Wong, K-L 2019, 'Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement', Advanced Therapeutics, vol. 2, no. 11, 1900068. https://doi.org/10.1002/adtp.201900068

TY - JOUR

T1 - Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

AU - Xie, Chen

AU - Chau, Ho-Fai

AU - Zhang, Jing-Xiang

AU - Tong, Sheng

AU - Jiang, Lijun

AU - Fok, Wan-Yiu

AU - Lung, Hong-Lok

AU - Zha, Shuai

AU - Zou, Rui

AU - Jiao, Ju

AU - Ng, Chi-Fai

AU - Ma, Ping'an

AU - Zhang, Junhui

AU - Lin, Jun

AU - Shiu, Kwok Keung

AU - Bünzli, Jean-Claude G.

AU - Wong, Wai-Kwok

AU - Long, Nicholas J.

AU - Law, Ga-Lai

AU - Wong, Ka-Leung

PY - 2019/11

Y1 - 2019/11

N2 - Acting as an extracellular matrix protein receptor, αVβ3 integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific αVβ3-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-Rn) are demonstrated as off-on theranostic agents, where Rn are specific peptides. Among them, Gd-PEG-R3 shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity of Gd-PEG-R3 is proven by its high αVβ3 integrin binding affinity in positive bladder cancer cells. All these findings support Gd-PEG-R3 as a promising bi-functional medical agent with both MRI contrasting ability and photodynamic therapeutic potential for curing bladder cancer. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - Acting as an extracellular matrix protein receptor, αVβ3 integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific αVβ3-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-Rn) are demonstrated as off-on theranostic agents, where Rn are specific peptides. Among them, Gd-PEG-R3 shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity of Gd-PEG-R3 is proven by its high αVβ3 integrin binding affinity in positive bladder cancer cells. All these findings support Gd-PEG-R3 as a promising bi-functional medical agent with both MRI contrasting ability and photodynamic therapeutic potential for curing bladder cancer. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - bladder cancer

KW - lanthanide

KW - magnetic resonance imaging

KW - photodynamic therapy

KW - porphyrin

UR - http://www.scopus.com/inward/record.url?scp=85080976482&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85080976482&origin=recordpage

U2 - 10.1002/adtp.201900068

DO - 10.1002/adtp.201900068

M3 - RGC 21 - Publication in refereed journal

SN - 2366-3987

VL - 2

JO - Advanced Therapeutics

JF - Advanced Therapeutics

IS - 11

M1 - 1900068

ER -

Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

Abstract

Funding

UN SDGs

Research Keywords

RGC Funding Information

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