Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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Detail(s)
Original language | English |
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Article number | 1700848 |
Journal / Publication | Advanced Science |
Volume | 5 |
Issue number | 5 |
Online published | 3 Mar 2018 |
Publication status | Published - May 2018 |
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DOI | DOI |
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Attachment(s) | Documents
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85042615596&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(21ec8707-b597-421f-a69d-c8f1b2533033).html |
Abstract
Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack of an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated with a thermosensitive hydrogel [poly(D,L-lactide)-poly(ethylene glycol)-poly(D,L-lactide) (PDLLA-PEG-PDLLA: PLEL)] to produce a new PTT system for postoperative treatment of cancer. The BP@PLEL hydrogel exhibits excellent near infrared (NIR) photothermal performance and a rapid NIR-induced sol–gel transition as well as good biodegradability and biocompatibility in vitro and in vivo. Based on these merits, an in vivo PTT postoperative treatment strategy is established. Under NIR irradiation, the sprayed BP@PLEL hydrogel enables rapid gelation forming a gelled membrane on wounds and offers high PTT efficacy to eliminate residual tumor tissues after tumor removal surgery. Furthermore, the good photothermal antibacterial performance prevents infection and this efficient and biodegradable PTT system is very promising in postoperative treatment of cancer.
Research Area(s)
- 2D materials, black phosphorus, near-infrared lasers, photothermal cancer therapy, thermosensitive hydrogels
Citation Format(s)
Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer. / Shao, Jundong; Ruan, Changshun; Xie, Hanhan et al.
In: Advanced Science, Vol. 5, No. 5, 1700848, 05.2018.
In: Advanced Science, Vol. 5, No. 5, 1700848, 05.2018.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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