Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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Author(s)

  • Jundong Shao
  • Changshun Ruan
  • Hanhan Xie
  • Zhibin Li
  • Huaiyu Wang
  • Xue-Feng Yu

Detail(s)

Original languageEnglish
Article number1700848
Journal / PublicationAdvanced Science
Volume5
Issue number5
Online published3 Mar 2018
Publication statusPublished - May 2018

Link(s)

Abstract

Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack of an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated with a thermosensitive hydrogel [poly(D,L-lactide)-poly(ethylene glycol)-poly(D,L-lactide) (PDLLA-PEG-PDLLA: PLEL)] to produce a new PTT system for postoperative treatment of cancer. The BP@PLEL hydrogel exhibits excellent near infrared (NIR) photothermal performance and a rapid NIR-induced sol–gel transition as well as good biodegradability and biocompatibility in vitro and in vivo. Based on these merits, an in vivo PTT postoperative treatment strategy is established. Under NIR irradiation, the sprayed BP@PLEL hydrogel enables rapid gelation forming a gelled membrane on wounds and offers high PTT efficacy to eliminate residual tumor tissues after tumor removal surgery. Furthermore, the good photothermal antibacterial performance prevents infection and this efficient and biodegradable PTT system is very promising in postoperative treatment of cancer.

Research Area(s)

  • 2D materials, black phosphorus, near-infrared lasers, photothermal cancer therapy, thermosensitive hydrogels

Citation Format(s)

Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer. / Shao, Jundong; Ruan, Changshun; Xie, Hanhan; Li, Zhibin; Wang, Huaiyu; Chu, Paul K.; Yu, Xue-Feng.

In: Advanced Science, Vol. 5, No. 5, 1700848, 05.2018.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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