Bismuth complexes inhibit the SARS coronavirus

Nan Yang; Julian A. Tanner; Bo-Jian Zheng; Rory M. Watt; Ming-Liang He; Lin-Yu Lu; Jie-Qing Jiang; Ka-To Shum; Yong-Ping Lin; Kin-Ling Wong; Marie C. M. Lin; Hsiang-Fu Kung; Hongzhe Sun; Jian-Dong Huang

doi:10.1002/anie.200701021

Bismuth complexes inhibit the SARS coronavirus

Nan Yang, Julian A. Tanner, Bo-Jian Zheng, Rory M. Watt, Ming-Liang He, Lin-Yu Lu, Jie-Qing Jiang, Ka-To Shum, Yong-Ping Lin, Kin-Ling Wong, Marie C. M. Lin, Hsiang-Fu Kung, Hongzhe Sun, Jian-Dong Huang

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

101 Citations (Scopus)

Abstract

Hold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	6464-6468
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	34
DOIs	https://doi.org/10.1002/anie.200701021
Publication status	Published - 2007
Externally published	Yes

Research Keywords

Antiviral agents
Bismuth
Enzymes
Helical structures
SARS coronavirus

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200701021

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title = "Bismuth complexes inhibit the SARS coronavirus",

abstract = "Hold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). {\textcopyright} 2007 Wiley-VCH Verlag GmbH & Co. KGaA.",

keywords = "Antiviral agents, Bismuth, Enzymes, Helical structures, SARS coronavirus",

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doi = "10.1002/anie.200701021",

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volume = "46",

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TY - JOUR

T1 - Bismuth complexes inhibit the SARS coronavirus

AU - Yang, Nan

AU - Tanner, Julian A.

AU - Zheng, Bo-Jian

AU - Watt, Rory M.

AU - He, Ming-Liang

AU - Lu, Lin-Yu

AU - Jiang, Jie-Qing

AU - Shum, Ka-To

AU - Lin, Yong-Ping

AU - Wong, Kin-Ling

AU - Lin, Marie C. M.

AU - Kung, Hsiang-Fu

AU - Sun, Hongzhe

AU - Huang, Jian-Dong

PY - 2007

Y1 - 2007

N2 - Hold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - Hold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

KW - Antiviral agents

KW - Bismuth

KW - Enzymes

KW - Helical structures

KW - SARS coronavirus

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U2 - 10.1002/anie.200701021

DO - 10.1002/anie.200701021

M3 - RGC 21 - Publication in refereed journal

C2 - 17645269

SN - 1433-7851

VL - 46

SP - 6464

EP - 6468

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 34

ER -

Bismuth complexes inhibit the SARS coronavirus

Abstract

Research Keywords

UN SDGs

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