Bismuth complexes inhibit the SARS coronavirus

Nan Yang; Julian A. Tanner; Bo-Jian Zheng; Rory M. Watt; Ming-Liang He; Lin-Yu Lu; Jie-Qing Jiang; Ka-To Shum; Yong-Ping Lin; Kin-Ling Wong; Marie C. M. Lin; Hsiang-Fu Kung; Hongzhe Sun; Jian-Dong Huang

doi:10.1002/anie.200701021

Author(s)

Nan Yang
Julian A. Tanner
Bo-Jian Zheng
Rory M. Watt
Lin-Yu Lu
Jie-Qing Jiang
Ka-To Shum
Yong-Ping Lin
Kin-Ling Wong
Marie C. M. Lin
Hsiang-Fu Kung
Hongzhe Sun
Jian-Dong Huang

Detail(s)

Original language	English
Pages (from-to)	6464-6468
Journal / Publication	Angewandte Chemie - International Edition
Volume	46
Issue number	34
Publication status	Published - 2007
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1002/anie.200701021 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-34548306443&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(411609e4-52db-46ac-8092-d6949f729686).html

Abstract

Hold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

Research Area(s)

Antiviral agents, Bismuth, Enzymes, Helical structures, SARS coronavirus

Citation Format(s)

[ RIS ] [ BibTeX ]

Bismuth complexes inhibit the SARS coronavirus. / Yang, Nan; Tanner, Julian A.; Zheng, Bo-Jian et al.

In: Angewandte Chemie - International Edition, Vol. 46, No. 34, 2007, p. 6464-6468.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Yang, N, Tanner, JA, Zheng, B-J, Watt, RM, He, M-L, Lu, L-Y, Jiang, J-Q, Shum, K-T, Lin, Y-P, Wong, K-L, Lin, MCM, Kung, H-F, Sun, H & Huang, J-D 2007, 'Bismuth complexes inhibit the SARS coronavirus', Angewandte Chemie - International Edition, vol. 46, no. 34, pp. 6464-6468. https://doi.org/10.1002/anie.200701021

Yang, N., Tanner, J. A., Zheng, B-J., Watt, R. M., He, M-L., Lu, L-Y., Jiang, J-Q., Shum, K-T., Lin, Y-P., Wong, K-L., Lin, M. C. M., Kung, H-F., Sun, H., & Huang, J-D. (2007). Bismuth complexes inhibit the SARS coronavirus. Angewandte Chemie - International Edition, 46(34), 6464-6468. https://doi.org/10.1002/anie.200701021

Yang N, Tanner JA, Zheng B-J, Watt RM, He M-L, Lu L-Y et al. Bismuth complexes inhibit the SARS coronavirus. Angewandte Chemie - International Edition. 2007;46(34):6464-6468. doi: 10.1002/anie.200701021

Yang, Nan ; Tanner, Julian A. ; Zheng, Bo-Jian et al. / Bismuth complexes inhibit the SARS coronavirus. In: Angewandte Chemie - International Edition. 2007 ; Vol. 46, No. 34. pp. 6464-6468.