Birth oxidative stress and the development of an antioxidant system in newborn piglets

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • J. Yin
  • W. Ren
  • G. Liu
  • J. Duan
  • L. Wu
  • T. Li
  • Y. Yin

Detail(s)

Original languageEnglish
Pages (from-to)1027-1035
Journal / PublicationFree Radical Research
Volume47
Issue number12
Publication statusPublished - Dec 2013
Externally publishedYes

Abstract

Birth oxidative stress is an oxidative response to a sudden transition process from maternal mediated respiration in uterus to autonomous pulmonary respiration outside the uterus. Meanwhile, oxidative stress has been demonstrated to be associated with various pathologies recorded in newborns. So, this research aimed to study the oxidative stress and the development of antioxidant system in newborn piglets. The measured variables include plasma lipid, protein and DNA oxidant injury, the activities of plasma antioxidant enzymes and the jejunal and ileal antioxidant gene expressions at 1, 7, 14, and 21 days after birth. Meanwhile, the nuclear factor erythroid 2-related factor 2 (Nrf2), transcription factor p65, and tumor protein 53 (p53) were determined by western blot. The results showed that newborn piglets suffered seriously from birth oxidative stress because of the naive antioxidant system. In addition, oxidant injury activated Nrf2 signaling pathway, resulting in the expression of antioxidant genes and release of antioxidant enzymes. With the development of antioxidant system, the oxidative balance gradually recovered on Day 7 after birth. In conclusion, birth caused oxidative stress and the oxidative balance gradually recovered with the development of antioxidant system. © 2013 Informa UK, Ltd.

Research Area(s)

  • Antioxidant system development, Birth oxidative stress, Newborn piglet

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Birth oxidative stress and the development of an antioxidant system in newborn piglets. / Yin, J.; Ren, W.; Liu, G. et al.
In: Free Radical Research, Vol. 47, No. 12, 12.2013, p. 1027-1035.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review