Biosynthesis of Depsides, Depsidones, and Diphenyl Ethers from Fungi and Lichens

Qiaolin Ji, Yudai Matsuda*

*Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Abstract

Depsides are a class of natural products in which two or more (poly)phenolic acid derivatives are linked by an ester bond. Depsides and related natural products, such as depsidones and diphenyl ethers, are widespread in nature and exhibit a wide range of biological activities. Although their biosynthesis has attracted considerable research interest for many decades, it remained largely elusive until recently. Recent studies have revealed the molecular mechanisms underlying the biosynthesis of several depsides and related natural products, uncovering unique enzymatic chemistry in their biosynthetic pathways. This review summarizes the biosynthetic pathways and mechanisms for depsides, depsidones, and diphenyl ethers, focusing on fungi and lichens, which are the primary producers of these compounds. © 2024 Wiley-VCH GmbH
Original languageEnglish
Article numbere202400451
JournalAsian Journal of Organic Chemistry
Volume14
Issue number2
Online published23 Dec 2024
DOIs
Publication statusPublished - Feb 2025

Funding

This work was supported by a grant from the City University of Hong Kong (Project No. 7006004).

Research Keywords

  • Biosynthesis
  • Depsides
  • Depsidones
  • Diphenyl ethers
  • Natural products
  • Polyketide synthases

Publisher's Copyright Statement

  • This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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