Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Jiaxiang Bai
  • Huaiyu Wang
  • Hao CHen
  • Gaoran Ge
  • Miao Wang
  • Liping Tong
  • Yaozeng Xu
  • Huiling Yang
  • Guoqing Pan
  • Dechun Geng

Detail(s)

Original languageEnglish
Article number120197
Number of pages15
Journal / PublicationBiomaterials
Volume255
Online published13 Jun 2020
Publication statusPublished - Oct 2020

Abstract

Bone endoprosthesis in patients with systemic chronic inflammation frequently leads to poor osseointegration after implantation mainly due to the increase in pro-inflammatory cytokines that induce bone resorption andimpair bone formation. In this work, peptide-coated implants are designed to create a beneficial bone immune microenvironment around prostheses to promote interfacial osteogenesis. By taking advantage of the spontaneous and stable coordination chemistry, Ti-based implants are coated with the mussel-inspired peptide to mitigate lipopolysaccharide (LPS)-induced inflammation by up-regulating the M2 phenotype of macrophages. In addition, the peptide coating increases the bone-implant contact (BIC) by nearly 3 times resulting in suppressed osteoclastogenesis and promoted osteogenesis by inhibiting the nuclear factor kappa-B (NF-κB) signalling pathway. Our findings indicate that biomimetic peptides with osteoimmunomodulatory bioactivity can be incorporated into Ti-based prostheses to facilitate bone regeneration in patients with chronic inflammatory diseases.

Research Area(s)

  • Biomimetic peptide, Osseointegration, Chronic inflammation, Ti implants, Osteoimmunomodulatory

Citation Format(s)

Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation. / Bai, Jiaxiang; Wang, Huaiyu; CHen, Hao; Ge, Gaoran; Wang, Miao; Gao, Ang; Tong, Liping; Xu, Yaozeng; Yang, Huiling; Pan, Guoqing; Chu, Paul K.; Geng, Dechun.

In: Biomaterials, Vol. 255, 120197, 10.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal