Biological toxicity estimates show involvement of a wider range of toxic compounds in sediments from Durban, South Africa than indicated from instrumental analyses

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Tash Vogt
  • Rialet Pieters
  • John Giesy
  • Brent K. Newman

Detail(s)

Original languageEnglish
Pages (from-to)49-57
Journal / PublicationMarine Pollution Bulletin
Volume138
Online published17 Nov 2018
Publication statusPublished - Jan 2019

Abstract

The toxic equivalences (TEQs) of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) from sediment of aquatic systems in Durban, South Africa were determined in two ways: 1) TEQs of PAHs and PCBs were determined by instrumental analyses and converted to 2,3,7,8‑tetrachlorodibenzo‑para‑dioxin equivalence (TCDDeq). 2) Bioassay equivalences (BEQs) of aryl hydrocarbon receptor (AhR) ligands were analysed using the H4IIE-luc bioassay. TEQs of PCBs ranged from below limit of detection (<LOD) to 57 pg TCDDeq·g−1 while PAHs ranged from <LOD to 790 pg TCDDeq·g−1. BEQs were 100- to 1000-fold greater than TEQs. Potency-balance revealed <10% of the BEQs were explained by instrumentally analysed compounds. Sediment quality guidelines indicated di minimis risk relating to TEQs, however had potential risk due to BEQs. The results reveal that far more AhR ligands were present in the sediments than what was instrumentally analysed and capable of causing AhR-mediated toxicity.

Research Area(s)

  • Africa, Aryl hydrocarbon receptor, Dioxin, H4IIE-luc, Harbour, SQGs

Citation Format(s)

Biological toxicity estimates show involvement of a wider range of toxic compounds in sediments from Durban, South Africa than indicated from instrumental analyses. / Vogt, Tash; Pieters, Rialet; Giesy, John et al.
In: Marine Pollution Bulletin, Vol. 138, 01.2019, p. 49-57.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review