Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-l-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT

A. H. Liao; F. I. Chou; Y. C. Kuo; H. W. Chen; J. J. Kai; C. W. Chang; F. D. Chen; J. J. Hwang

doi:10.1016/j.apradiso.2009.12.033

Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-l-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT

A. H. Liao
, F. I. Chou
, Y. C. Kuo
, H. W. Chen
, J. J. Kai
, C. W. Chang
, F. D. Chen
, J. J. Hwang

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

7 Citations (Scopus)

Abstract

A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2 h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4 h post PBAD-lipiodol injection. © 2009 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	422-426
Journal	Applied Radiation and Isotopes
Volume	68
Issue number	3
DOIs	https://doi.org/10.1016/j.apradiso.2009.12.033
Publication status	Published - Mar 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Biodistribution
BNCT
BPA-fructose
GP7TB liver tumor
PBAD-lipiodol

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10.1016/j.apradiso.2009.12.033

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title = "Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-l-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT",

abstract = "A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2 h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4 h post PBAD-lipiodol injection. {\textcopyright} 2009 Elsevier Ltd. All rights reserved.",

keywords = "Biodistribution, BNCT, BPA-fructose, GP7TB liver tumor, PBAD-lipiodol",

author = "Liao, \{A. H.\} and Chou, \{F. I.\} and Kuo, \{Y. C.\} and Chen, \{H. W.\} and Kai, \{J. J.\} and Chang, \{C. W.\} and Chen, \{F. D.\} and Hwang, \{J. J.\}",

year = "2010",

month = mar,

doi = "10.1016/j.apradiso.2009.12.033",

language = "English",

volume = "68",

pages = "422--426",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Ltd.",

number = "3",

}

Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-l-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT. / Liao, A. H.; Chou, F. I.; Kuo, Y. C. et al.
In: Applied Radiation and Isotopes, Vol. 68, No. 3, 03.2010, p. 422-426.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-l-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT

AU - Liao, A. H.

AU - Chou, F. I.

AU - Kuo, Y. C.

AU - Chen, H. W.

AU - Kai, J. J.

AU - Chang, C. W.

AU - Chen, F. D.

AU - Hwang, J. J.

PY - 2010/3

Y1 - 2010/3

N2 - A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2 h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4 h post PBAD-lipiodol injection. © 2009 Elsevier Ltd. All rights reserved.

AB - A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2 h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4 h post PBAD-lipiodol injection. © 2009 Elsevier Ltd. All rights reserved.

KW - Biodistribution

KW - BNCT

KW - BPA-fructose

KW - GP7TB liver tumor

KW - PBAD-lipiodol

UR - https://www.scopus.com/pages/publications/74449092523

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-74449092523&origin=recordpage

U2 - 10.1016/j.apradiso.2009.12.033

DO - 10.1016/j.apradiso.2009.12.033

M3 - RGC 21 - Publication in refereed journal

C2 - 20056428

SN - 0969-8043

VL - 68

SP - 422

EP - 426

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 3

ER -

Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-l-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT

Abstract

UN SDGs

Research Keywords

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