Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-l-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • A. H. Liao
  • F. I. Chou
  • Y. C. Kuo
  • H. W. Chen
  • C. W. Chang
  • F. D. Chen
  • J. J. Hwang

Detail(s)

Original languageEnglish
Pages (from-to)422-426
Journal / PublicationApplied Radiation and Isotopes
Volume68
Issue number3
Publication statusPublished - Mar 2010
Externally publishedYes

Abstract

A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2 h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4 h post PBAD-lipiodol injection. © 2009 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Biodistribution, BNCT, BPA-fructose, GP7TB liver tumor, PBAD-lipiodol

Citation Format(s)

Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-l-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT. / Liao, A. H.; Chou, F. I.; Kuo, Y. C. et al.
In: Applied Radiation and Isotopes, Vol. 68, No. 3, 03.2010, p. 422-426.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review